Kinetics of Weak Distance-Dependent Hole Transfer in DNA by Adenine-Hopping Mechanism

2003 ◽  
Vol 125 (23) ◽  
pp. 6842-6843 ◽  
Author(s):  
Kiyohiko Kawai ◽  
Tadao Takada ◽  
Sachiko Tojo ◽  
Tetsuro Majima
Keyword(s):  
Hole Transfer ◽  
Hopping Mechanism ◽  
Kinetics Of

scholarly journals Photosensitized one-electron oxidation of DNA

2005 ◽  
Vol 77 (6) ◽  
pp. 963-975 ◽  
Author(s):  
Kiyohiko Kawai ◽  
Tetsuro Majima
Keyword(s):  
Dna Damage ◽  
High Performance ◽  
Transient Absorption ◽  
Basic Mechanism ◽  
Absorption Measurement ◽  
Mechanistic Study ◽  
Hole Transfer ◽  
Damage Quantification ◽  
Oxidation Of Dna ◽  
Kinetics Of

Photosensitized one-electron oxidation of DNA has attracted much interest because it causes oxidative damage which leads to mutation, and because it is involved in the basic mechanism of photodynamic therapy. In the present article, we describe the mechanistic study of photosensitized DNA damage, especially addressing the kinetics of hole transfer by adenine(A)-hopping and its effect on the DNA damage. The combination of the transient absorption measurement and DNA damage quantification by high-performance liquid chromatography clearly demonstrate that the yield of the DNA damage correlates well with the lifetime of the charge-separated state caused by A-hopping, showing that hole transfer helps DNA damage. These findings led us to propose a new method to accomplish the efficient DNA damage using a combination of two-color, two-laser irradiation.

scholarly journals Enhanced Kinetics of Hole Transfer and Electrocatalysis during Photocatalytic Oxygen Evolution by Cocatalyst Tuning

ACS Catalysis ◽  
2016 ◽  
Vol 6 (7) ◽  
pp. 4117-4126 ◽  
Author(s):  
Ela Nurlaela ◽  
Hai Wang ◽  
Tatsuya Shinagawa ◽  
Sean Flanagan ◽  
Samy Ould-Chikh ◽  
...  
Keyword(s):  
Oxygen Evolution ◽  
Hole Transfer ◽  
Kinetics Of

How Surface Potential Determines the Kinetics of the First Hole Transfer of Photocatalytic Water Oxidation

2014 ◽  
Vol 136 (30) ◽  
pp. 10632-10639 ◽  
Author(s):  
Matthias M. Waegele ◽  
Xihan Chen ◽  
David M. Herlihy ◽  
Tanja Cuk
Keyword(s):  
Surface Potential ◽  
Water Oxidation ◽  
Hole Transfer ◽  
Kinetics Of

scholarly journals The Dynamics of Hole Transfer in DNA

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4044 ◽  
Author(s):  
Andrea Peluso ◽  
Tonino Caruso ◽  
Alessandro Landi ◽  
Amedeo Capobianco
Keyword(s):  
High Energy ◽  
Hole Transport ◽  
Charge Hole ◽  
Hole Transfer ◽  
High Energy Radiation ◽  
Specific Effects ◽  
Redox Sensing ◽  
Hole Migration ◽  
Kinetics Of ◽  
Disease Understanding

High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects.

Hole Transfer Kinetics of DNA

2013 ◽  
Vol 46 (11) ◽  
pp. 2616-2625 ◽  
Author(s):  
Kiyohiko Kawai ◽  
Tetsuro Majima
Keyword(s):  
Hole Transfer ◽  
Kinetics Of

Kinetics of Multistep Hole Transfer in DNA by Monitoring the Transient Absorption of the Pyrene Radical Cation

2003 ◽  
Vol 107 (50) ◽  
pp. 14052-14057 ◽  
Author(s):  
Tadao Takada ◽  
Kiyohiko Kawai ◽  
Sachiko Tojo ◽  
Tetsuro Majima
Keyword(s):  
Radical Cation ◽  
Transient Absorption ◽  
Hole Transfer ◽  
Kinetics Of

Direct observations of radiation-enhanced transformations in glass

1983 ◽  
Vol 41 ◽  
pp. 354-355
Author(s):  
J. F. DeNatale ◽  
D. G. Howitt
Keyword(s):  
Glass Matrix ◽  
Diffusion Mechanism ◽  
Bubble Formation ◽  
Silicate Glasses ◽  
Phase Decomposition ◽  
Direct Observations ◽  
Thin Foils ◽  
Oxygen Bubble ◽  
Electron Energy Loss ◽  
Kinetics Of

The electron irradiation of silicate glasses containing metal cations produces various types of phase separation and decomposition which includes oxygen bubble formation at intermediate temperatures figure I. The kinetics of bubble formation are too rapid to be accounted for by oxygen diffusion but the behavior is consistent with a cation diffusion mechanism if the amount of oxygen in the bubble is not significantly different from that in the same volume of silicate glass. The formation of oxygen bubbles is often accompanied by precipitation of crystalline phases and/or amorphous phase decomposition in the regions between the bubbles and the detection of differences in oxygen concentration between the bubble and matrix by electron energy loss spectroscopy cannot be discerned (figure 2) even when the bubble occupies the majority of the foil depth.The oxygen bubbles are stable, even in the thin foils, months after irradiation and if van der Waals behavior of the interior gas is assumed an oxygen pressure of about 4000 atmospheres must be sustained for a 100 bubble if the surface tension with the glass matrix is to balance against it at intermediate temperatures.

Irradiation behavior of pyrolytic silicon carbide

1983 ◽  
Vol 41 ◽  
pp. 72-73
Author(s):  
R. J. Lauf
Keyword(s):  
Silicon Carbide ◽  
Fission Products ◽  
Thermodynamics And Kinetics ◽  
Neutron Fluences ◽  
Fuel Particles ◽  
Sic Coatings ◽  
Irradiation Behavior ◽  
Kinetics Of ◽  
Htgr Fuel

Fuel particles for the High-Temperature Gas-Cooled Reactor (HTGR) contain a layer of pyrolytic silicon carbide to act as a miniature pressure vessel and primary fission product barrier. Optimization of the SiC with respect to fuel performance involves four areas of study: (a) characterization of as-deposited SiC coatings; (b) thermodynamics and kinetics of chemical reactions between SiC and fission products; (c) irradiation behavior of SiC in the absence of fission products; and (d) combined effects of irradiation and fission products. This paper reports the behavior of SiC deposited on inert microspheres and irradiated to fast neutron fluences typical of HTGR fuel at end-of-life.

The Ordered Phase Formation in Ti-Al-Ga Alloys

1970 ◽  
Vol 28 ◽  
pp. 440-441
Author(s):  
Shiro Fujishiro ◽  
Harold L. Gegel
Keyword(s):  
Thermal Stability ◽  
High Temperature ◽  
Titanium Alloys ◽  
Growth Kinetics ◽  
Stoichiometric Composition ◽  
Good Potential ◽  
Alpha Titanium ◽  
Cold Rolled ◽  
Kinetics Of ◽  
Thermal Stability Of

Ordered-alpha titanium alloys having a DO19 type structure have good potential for high temperature (600°C) applications, due to the thermal stability of the ordered phase and the inherent resistance to recrystallization of these alloys. Five different Ti-Al-Ga alloys consisting of equal atomic percents of aluminum and gallium solute additions up to the stoichiometric composition, Ti3(Al, Ga), were used to study the growth kinetics of the ordered phase and the nature of its interface.The alloys were homogenized in the beta region in a vacuum of about 5×10-7 torr, furnace cooled; reheated in air to 50°C below the alpha transus for hot working. The alloys were subsequently acid cleaned, annealed in vacuo, and cold rolled to about. 050 inch prior to additional homogenization

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