Protein-Conjugated Nanoparticles from Rapid Expansion of Supercritical Fluid Solution into Aqueous Solution

2003 ◽  
Vol 125 (26) ◽  
pp. 8015-8018 ◽  
Author(s):  
Mohammed J. Meziani ◽  
Ya-Ping Sun
Keyword(s):  
Aqueous Solution ◽  
Supercritical Fluid ◽  
Rapid Expansion ◽  
Fluid Solution

Synthesis of Nanostructured Iron Oxide(III) Powders by Rapid Expansion of Supercritical Fluid Solutions

1998 ◽  
Vol 520 ◽  
Author(s):  
A.A. Burukhin ◽  
B.R. Churagulov ◽  
N.N. Oleynikov ◽  
Yu.V. Kolen'Ko
Keyword(s):  
Aqueous Solution ◽  
Thermal Decomposition ◽  
Iron Oxide ◽  
Solid State ◽  
Supercritical Fluid ◽  
Solid State Reaction ◽  
Zinc Ferrite ◽  
Rapid Expansion ◽  
Molar Ratio ◽  
Supercritical Aqueous Solution

ABSTRACTNanostructured a-Fe2O3 powders were generated by rapid expansion of supercritical fluid solutions (RESS, T=773 K, P=100 MPa) and by rapid thermal decomposition of precursors in solution ( RTDS, T=623 K, P=100 MPa) on lab RESS-setup from 0,040 M and 0,10 M aqueous solutions of Fe(NO3)3. The size of subcrystallites is about 22-29 nm. Comparison of reactivity of α-Fe2O3 powders in a model solid state reaction between a-Fe2O3 powders (generated by RESS from 0,040 M solution) and Li2CO3 (mole ratio 1:1) with literature data on a-Fe2O3 powders produced by other methods shows that its reactivity is markedly higher. A basic essence possibility of zinc ferrite ZnFe2O4 formation immediately at the stage of the rapid expansion (T=773K; P=100 MPa) of a supercritical aqueous solution of zinc and iron nitrates (molar ratio Zn:Fe=1:2; C=0. 1 M) was shown.

Polymeric Nanoparticles from Rapid Expansion of Supercritical Fluid Solution

2005 ◽  
Vol 11 (5) ◽  
pp. 1366-1373 ◽  
Author(s):  
Ya-Ping Sun ◽  
Mohammed J. Meziani ◽  
Pankaj Pathak ◽  
Liangwei Qu
Keyword(s):  
Supercritical Fluid ◽  
Polymeric Nanoparticles ◽  
Rapid Expansion ◽  
Fluid Solution

Polymeric Nanoparticles from Rapid Expansion of Supercritical Fluid Solution

ChemInform ◽  
2006 ◽  
Vol 37 (10) ◽  
Author(s):  
Ya-Ping Sun ◽  
Mohammed J. Meziani ◽  
Pankaj Pathak ◽  
Liangwei Qu
Keyword(s):  
Supercritical Fluid ◽  
Polymeric Nanoparticles ◽  
Rapid Expansion ◽  
Fluid Solution

scholarly journals Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation

ADMET & DMPK ◽  
2020 ◽  
Author(s):  
Shashi Kiran Misra ◽  
Kamla Pathak
Keyword(s):  
Supercritical Fluid ◽  
High Throughput Screening ◽  
Green Technology ◽  
Water Soluble ◽  
Rapid Expansion ◽  
Particle Generation ◽  
Particulate Solids ◽  
Supercritical Fluid Technology ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

<p class="ADMETabstracttext">Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids. Poor solubility and bioavailability of these pharmaceuticals are challenging attributes confronted by a formulator during product development. Hence, substantial efforts have been directed into the research on particle generation techniques. Although the conventional methods, such as crushing or milling and crystallization or precipitation, are still used; supercritical fluid technology introduced in the mid-1980s presents a new method of particle generation. Supercritical fluid processes not only produce micro- and nanoparticles with a narrow size distribution, they are also employed for the microencapsulation, cocrystallization, and surface coating with polymer. Recognized as a green technology, it has emerged as successful variants chiefly as Rapid Expansion of supercritical solutions (RESS), Supercritical anti-solvent (SAS) and Particles from Gas Saturated Solution (PGSS) depending upon type of solvent, solute, antisolvent and nebulization techniques. Being economical and eco-friendly, supercritical fluid technolgy has garnered considerable interest both in academia and industry for modification of physicochemical properties such as particle size, shape, density and ultimately solubility. The current manuscript is a comprehensive update on different supercritical fluid processes used for particle generation with the purpose of solubility enhancement of drugs and hence bioavailability.</p>

Photoinduced Isomerization Kinetics of Diiodomethane in Supercritical Fluid Solution:  Local Density Effects†

2006 ◽  
Vol 110 (9) ◽  
pp. 3320-3329 ◽  
Author(s):  
Christian Grimm ◽  
Alexander Kandratsenka ◽  
Philipp Wagener ◽  
Jochen Zerbs ◽  
Jörg Schroeder
Keyword(s):  
Supercritical Fluid ◽  
Local Density ◽  
Fluid Solution ◽  
Density Effects ◽  
Kinetics Of ◽  
Photoinduced Isomerization
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