Polymeric Nanoparticles from Rapid Expansion of Supercritical Fluid Solution

ChemInform ◽  
2006 ◽  
Vol 37 (10) ◽  
Author(s):  
Ya-Ping Sun ◽  
Mohammed J. Meziani ◽  
Pankaj Pathak ◽  
Liangwei Qu
Keyword(s):  
Supercritical Fluid ◽  
Polymeric Nanoparticles ◽  
Rapid Expansion ◽  
Fluid Solution

Polymeric Nanoparticles from Rapid Expansion of Supercritical Fluid Solution

2005 ◽  
Vol 11 (5) ◽  
pp. 1366-1373 ◽  
Author(s):  
Ya-Ping Sun ◽  
Mohammed J. Meziani ◽  
Pankaj Pathak ◽  
Liangwei Qu
Keyword(s):  
Supercritical Fluid ◽  
Polymeric Nanoparticles ◽  
Rapid Expansion ◽  
Fluid Solution

scholarly journals Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation

ADMET & DMPK ◽  
2020 ◽  
Author(s):  
Shashi Kiran Misra ◽  
Kamla Pathak
Keyword(s):  
Supercritical Fluid ◽  
High Throughput Screening ◽  
Green Technology ◽  
Water Soluble ◽  
Rapid Expansion ◽  
Particle Generation ◽  
Particulate Solids ◽  
Supercritical Fluid Technology ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

<p class="ADMETabstracttext">Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids. Poor solubility and bioavailability of these pharmaceuticals are challenging attributes confronted by a formulator during product development. Hence, substantial efforts have been directed into the research on particle generation techniques. Although the conventional methods, such as crushing or milling and crystallization or precipitation, are still used; supercritical fluid technology introduced in the mid-1980s presents a new method of particle generation. Supercritical fluid processes not only produce micro- and nanoparticles with a narrow size distribution, they are also employed for the microencapsulation, cocrystallization, and surface coating with polymer. Recognized as a green technology, it has emerged as successful variants chiefly as Rapid Expansion of supercritical solutions (RESS), Supercritical anti-solvent (SAS) and Particles from Gas Saturated Solution (PGSS) depending upon type of solvent, solute, antisolvent and nebulization techniques. Being economical and eco-friendly, supercritical fluid technolgy has garnered considerable interest both in academia and industry for modification of physicochemical properties such as particle size, shape, density and ultimately solubility. The current manuscript is a comprehensive update on different supercritical fluid processes used for particle generation with the purpose of solubility enhancement of drugs and hence bioavailability.</p>

Photoinduced Isomerization Kinetics of Diiodomethane in Supercritical Fluid Solution:  Local Density Effects†

2006 ◽  
Vol 110 (9) ◽  
pp. 3320-3329 ◽  
Author(s):  
Christian Grimm ◽  
Alexander Kandratsenka ◽  
Philipp Wagener ◽  
Jochen Zerbs ◽  
Jörg Schroeder
Keyword(s):  
Supercritical Fluid ◽  
Local Density ◽  
Fluid Solution ◽  
Density Effects ◽  
Kinetics Of ◽  
Photoinduced Isomerization
Sign in / Sign up

Export Citation Format

Share Document