scholarly journals 19F,1H-HOESY and PGSE NMR Studies of Neutral Trinuclear Complexes of AuIand HgII:  Evidence for Acid−Base Stacking in Solution

2002 ◽  
Vol 124 (17) ◽  
pp. 4570-4571 ◽  
Author(s):  
Alfredo Burini ◽  
John P. Fackler, ◽  
Rossana Galassi ◽  
Alceo Macchioni ◽  
Mohammad A. Omary ◽  
...  
Keyword(s):  
Base Stacking ◽  
Acid Base ◽  
Nmr Studies ◽  
Trinuclear Complexes ◽  
Pgse Nmr

Finding and visualizing nucleic acid base stacking

1996 ◽  
Vol 14 (1) ◽  
pp. 6-11 ◽  
Author(s):  
H.A. Gabb ◽  
S.R. Sanghani ◽  
C.H. Robert ◽  
C. Prévost
Keyword(s):  
Nucleic Acid ◽  
Base Stacking ◽  
Acid Base ◽  
Nucleic Acid Base

scholarly journals The Palladium(II) Complex of Aβ4−16 as Suitable Model for Structural Studies of Biorelevant Copper(II) Complexes of N-Truncated Beta-Amyloids

2020 ◽  
Vol 21 (23) ◽  
pp. 9200
Author(s):  
Mariusz Mital ◽  
Kosma Szutkowski ◽  
Karolina Bossak-Ahmad ◽  
Piotr Skrobecki ◽  
Simon C. Drew ◽  
...  
Keyword(s):  
Supramolecular Assembly ◽  
Ros Generation ◽  
Suitable Model ◽  
Nmr Studies ◽  
Exchange Processes ◽  
Square Planar ◽  
Synthetic Procedure ◽  
Complex Forms ◽  
Pgse Nmr ◽  
Kinetic Trapping

The Aβ4−42 peptide is a major beta-amyloid species in the human brain, forming toxic aggregates related to Alzheimer’s Disease. It also strongly chelates Cu(II) at the N-terminal Phe-Arg-His ATCUN motif, as demonstrated in Aβ4−16 and Aβ4−9 model peptides. The resulting complex resists ROS generation and exchange processes and may help protect synapses from copper-related oxidative damage. Structural characterization of Cu(II)Aβ4−x complexes by NMR would help elucidate their biological function, but is precluded by Cu(II) paramagneticism. Instead we used an isostructural diamagnetic Pd(II)-Aβ4−16 complex as a model. To avoid a kinetic trapping of Pd(II) in an inappropriate transient structure, we designed an appropriate pH-dependent synthetic procedure for ATCUN Pd(II)Aβ4−16, controlled by CD, fluorescence and ESI-MS. Its assignments and structure at pH 6.5 were obtained by TOCSY, NOESY, ROESY, 1H-13C HSQC and 1H-15N HSQC NMR experiments, for natural abundance 13C and 15N isotopes, aided by corresponding experiments for Pd(II)-Phe-Arg-His. The square-planar Pd(II)-ATCUN coordination was confirmed, with the rest of the peptide mostly unstructured. The diffusion rates of Aβ4−16, Pd(II)-Aβ4−16 and their mixture determined using PGSE-NMR experiment suggested that the Pd(II) complex forms a supramolecular assembly with the apopeptide. These results confirm that Pd(II) substitution enables NMR studies of structural aspects of Cu(II)-Aβ complexes.

NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5′-Phosphate Acid–Base in Alanine Racemase, Aspartate Aminotransferase, and Poly-l-lysine

2013 ◽  
Vol 135 (48) ◽  
pp. 18160-18175 ◽  
Author(s):  
Monique Chan-Huot ◽  
Alexandra Dos ◽  
Reinhard Zander ◽  
Shasad Sharif ◽  
Peter M. Tolstoy ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Aspartate Aminotransferase ◽  
Alanine Racemase ◽  
Acid Base ◽  
Nmr Studies

scholarly journals The Physical Basis of Nucleic Acid Base Stacking in Water

2001 ◽  
Vol 80 (1) ◽  
pp. 140-148 ◽  
Author(s):  
Ray Luo ◽  
Hillary S.R. Gilson ◽  
Michael J. Potter ◽  
Michael K. Gilson
Keyword(s):  
Nucleic Acid ◽  
Physical Basis ◽  
Base Stacking ◽  
Acid Base ◽  
Nucleic Acid Base

PGSE NMR Studies on RAPTA Derivatives: Evidence for the Formation of H-Bonded Dicationic Species

2008 ◽  
Vol 27 (7) ◽  
pp. 1649-1652 ◽  
Author(s):  
Sandra Bolaño ◽  
Gianluca Ciancaleoni ◽  
Jorge Bravo ◽  
Luca Gonsalvi ◽  
Alceo Macchioni ◽  
...  
Keyword(s):  
Nmr Studies ◽  
Pgse Nmr

Transport heterogeneity in porous pellets—I. PGSE NMR studies

1995 ◽  
Vol 50 (2) ◽  
pp. 309-326 ◽  
Author(s):  
Michael P. Hollewand ◽  
Lynn F. Gladden
Keyword(s):  
Nmr Studies ◽  
Pgse Nmr
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