Reactions of Perchloryl Fluoride with Organic Compounds. II. Fluorination of Certain Active Methylene Compounds1

1958 ◽  
Vol 80 (24) ◽  
pp. 6533-6535 ◽  
Author(s):  
C. E. Inman ◽  
R. E. Oesterling ◽  
E. A. Tyczkowski
Keyword(s):  
Organic Compounds ◽  
Perchloryl Fluoride ◽  
Active Methylene

Reactions of Perchloryl Fluoride with Organic Compounds. I. Perchlorylation of Aromatic Compounds1

1958 ◽  
Vol 80 (19) ◽  
pp. 5286-5288 ◽  
Author(s):  
C. E. Inman ◽  
R. E. Oesterling ◽  
E. A. Tyczkowski
Keyword(s):  
Organic Compounds ◽  
Perchloryl Fluoride

A γ-Fluoro β-Acetoxypropyl Sulfonium Salt as an Equivalent of a (Fluoromethyl)vinyl Sulfonium Salt: Reagent for the Facile Synthesis of Monofluoromethylated Cyclopropanes or Aziridines

Synlett ◽  
2018 ◽  
Vol 29 (18) ◽  
pp. 2372-2376 ◽  
Author(s):  
Takeshi Hanamoto ◽  
Yuuri Fujiwara ◽  
Ryuhei Muta ◽  
Keiichi Sato ◽  
Hiroaki Haramura ◽  
...  
Keyword(s):  
Organic Compounds ◽  
Easy Access ◽  
Facile Synthesis ◽  
Sulfonium Salt ◽  
Active Methylene Compounds ◽  
Active Methylene

A β-monofluoromethylated vinyl sulfonium salt, prepared in situ from a precursor γ-fluoro β-acetoxypropyl sulfonium salt under mild basic conditions, reacted with a lvariety of active methylene compounds or a primary sulfone amide under basic conditions to provide the corresponding monofluoromethylated three-membered rings in good-to-excellent yields. This new sulfonium reagent should permit easy access to a variety of important monofluoromethylated organic compounds.

A novel fluorination reaction: The interaction of perchloryl fluoride with active methylene compounds

1958 ◽  
Vol 14 (10) ◽  
pp. 355-355 ◽  
Author(s):  
C. E. Inman ◽  
E. A. Tyczkowski ◽  
R. E. Oesterling ◽  
F. L. Scott
Keyword(s):  
Active Methylene Compounds ◽  
Perchloryl Fluoride ◽  
Active Methylene

scholarly journals ALKYLATION OF TRIETHYL ESTER OF PHOSPHONOACETIC ACID AND DIETHOXYCYANOMETHYLPHOSPHONATE WITH HALOIDACETALS AND PRODUCTS OF THEIR TRANSFORMATION

2017 ◽  
Vol 60 (2) ◽  
pp. 13
Author(s):  
Valekh M. Ismailov ◽  
Niftaly N. Yusubov ◽  
Nurlana D. Sadykhova ◽  
Gezal G. Ibragimova ◽  
Iskander A. Mamedov
Keyword(s):  
Nmr Spectroscopy ◽  
Carbon Atom ◽  
Carbonyl Group ◽  
Organic Compounds ◽  
Phosphonoacetic Acid ◽  
Ir And Nmr Spectroscopy ◽  
High Reaction ◽  
Hydrolysis Of ◽  
Active Methylene ◽  
Methylene Group

The method was developed for synthesis of hard-to-reach phosphorylated aldehides with hidden carbonyl group. As compounds with active methylene group triethyl ethers of phosfonacetic acid and diethoxycianomethyl phosfonate were used at the condensation with bromo- and chloroacetals to produce the corresponding acetals. It was found that in the mentioned phosphonates the alkylation by haloid acetal occurs exceptionally on the carbon atom of active methylene group, not touching the nitrile and ester groups. The hydrolysis of obtained phosphorylated acetals led to preparation of phosphorylated aldehydes. It was found that an application of chlorinated acetals led to decreasing the yield of final products. On the basis of obtained aldehydes the corresponding hydrozones were prepared. The latter in the course of reaction undergoes the conversion occurring on the nitrile and ester groups. The high reaction activity of synthesized phosphorylated acetals was used in the further synthesis of different kind of phosphoroganic compounds.  The reaction of phosphorylated aldehydes with hydrazine led to obtaining the nitrogen and phosphor containing organic compounds. The structures of synthesized compounds were studied and proved by IR and NMR spectroscopy methods. Forcitation:                                                                                                                    Ismailov V.M., Yusubov N.N., Sadykhova N.D., Ibragimova G.G., Mamedov I.A. Alkylation of triethyl ester of phosphonoacetic acid and diethoxycyanomethylphosphonate with haloidacetals and products of their transformation. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 2. P. 13-16.

The Tempo and mode(S) of Prebiotic Evolution

1997 ◽  
Vol 161 ◽  
pp. 419-429 ◽  
Author(s):  
Antonio Lazcano
Keyword(s):  
Origin Of Life ◽  
Organic Compounds ◽  
Biological Evolution ◽  
Current Evidence ◽  
Early Diversification ◽  
Time Period ◽  
The Galaxy ◽  
History Of ◽  
Widespread Phenomenon ◽  
The Origin Of Life

AbstractDifferent current ideas on the origin of life are critically examined. Comparison of the now fashionable FeS/H2S pyrite-based autotrophic theory of the origin of life with the heterotrophic viewpoint suggest that the later is still the most fertile explanation for the emergence of life. However, the theory of chemical evolution and heterotrophic origins of life requires major updating, which should include the abandonment of the idea that the appearance of life was a slow process involving billions of years. Stability of organic compounds and the genetics of bacteria suggest that the origin and early diversification of life took place in a time period of the order of 10 million years. Current evidence suggest that the abiotic synthesis of organic compounds may be a widespread phenomenon in the Galaxy and may have a deterministic nature. However, the history of the biosphere does not exhibits any obvious trend towards greater complexity or «higher» forms of life. Therefore, the role of contingency in biological evolution should not be understimated in the discussions of the possibilities of life in the Universe.

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