Synthesis of adamantane derivatives. VIII. Novel substitution reaction of adamantanone. A simple synthesis of bicyclo[3.3.1]non-2-ene-7-carboxylic acid

1969 ◽  
Vol 91 (12) ◽  
pp. 3390-3391 ◽  
Author(s):  
Tadashi Sasaki ◽  
Shoji Eguchi ◽  
Takeshi Toru
Keyword(s):  
Carboxylic Acid ◽  
Substitution Reaction ◽  
Simple Synthesis ◽  
Adamantane Derivatives

A Simple Synthesis of 4-Substituted 2-(3-Hydroxy-2-oxo-1-phenethylpropylcarbamoyl) pyrrolidine-1-carboxylic Acid Benzyl Esters as Novel Cysteine Protease Inhibitors

2008 ◽  
Vol 63 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Seikwan Oh ◽  
Jae-Chul Jung ◽  
Mitchell A. Avery
Keyword(s):  
Carboxylic Acid ◽  
Protease Inhibitors ◽  
Cysteine Protease ◽  
Good Yield ◽  
Sodium Acetate ◽  
Simple Synthesis ◽  
Insertion Reaction ◽  
Cysteine Protease Inhibitors ◽  
Convenient Synthesis ◽  
Benzyl Esters

A convenient synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1-phenethylpropylcarbamoyl)pyrrolidine- 1-carboxylic acid benzyl esters 17 and 18 as new cysteine protease inhibitors is described. The synthetic key strategies involve the diazocarbonyl insertion reaction of N-Boc-L-homophenylalanine (1) by diazomethane, acetylation of the bromoketone 2 with sodium acetate, and condensation of acids 12, 14 with (3S)-3-amino-2-oxo-5-phenyl-pentyl acetate monohydrochloride (4) in good yield

A simple synthesis of ketone from carboxylic acid using tosyl chloride as an activator

2019 ◽  
Vol 60 (39) ◽  
pp. 151084
Author(s):  
Debasis Sahoo ◽  
Sohini Sarkar ◽  
Samaresh Jana
Keyword(s):  
Carboxylic Acid ◽  
Simple Synthesis ◽  
Tosyl Chloride

Simple Synthesis of Aldehyde and Carboxylic Acid Terminated Methoxypoly(ethylene glycol)

2016 ◽  
Vol 217 (15) ◽  
pp. 1745-1751 ◽  
Author(s):  
Javier F. Guastavino ◽  
Victoria A. Vaillard ◽  
Mariano D. Cristaldi ◽  
Lorena Rossini ◽  
Santiago E. Vaillard
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Simple Synthesis

ChemInform Abstract: A Simple Synthesis of the Ripening Agent 1-Aminocyclopropane-1- carboxylic Acid.

ChemInform ◽  
2010 ◽  
Vol 24 (36) ◽  
pp. no-no
Author(s):  
P. M. ANGUS ◽  
B. T. GOLDING ◽  
A. M. SARGESON
Keyword(s):  
Carboxylic Acid ◽  
Simple Synthesis
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