Conformation of cyclic peptides. VIII. Cyclic hexapeptides containing the L-pro-D-phe sequence

1974 ◽  
Vol 96 (8) ◽  
pp. 2597-2605 ◽  
Author(s):  
Kenneth D. Kopple ◽  
Thomas J. Schamper ◽  
Anita Go
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Hexapeptides

ChemInform Abstract: CONFORMATION OF CYCLIC PEPTIDES PART 7, CYCLIC HEXAPEPTIDES CONTAINING THE D-PHE-L-PRO SEQUENCE

1973 ◽  
Vol 4 (45) ◽  
pp. no-no
Author(s):  
KENNETH D. KOPPLE ◽  
ANITA GO ◽  
THOMAS J. SCHAMPER ◽  
CRAIG S. WILCOX
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Hexapeptides

Conformation of cyclic peptides. VII. Cyclic hexapeptides containing the D-Phe-L-Pro sequence

1973 ◽  
Vol 95 (18) ◽  
pp. 6090-6096 ◽  
Author(s):  
Kenneth D. Kopple ◽  
Anita. Go ◽  
Thomas J. Schamper ◽  
Craig S. Wilcox
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Hexapeptides

Toward accurately modeling N-methylated cyclic peptides

2017 ◽  
Vol 19 (7) ◽  
pp. 5377-5388 ◽  
Author(s):  
Diana P. Slough ◽  
Hongtao Yu ◽  
Sean M. McHugh ◽  
Yu-Shan Lin
Keyword(s):  
Structure Prediction ◽  
Cyclic Peptides ◽  
Sampling Methods ◽  
Enhanced Sampling ◽  
Cyclic Hexapeptides

Structure prediction of benchmark N-methylated cyclic hexapeptides using enhanced sampling methods.

scholarly journals Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 701
Author(s):  
Jieyi Long ◽  
Yaqi Chen ◽  
Weihao Chen ◽  
Junfeng Wang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Soft Coral ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
X Ray ◽  
Cyclic Hexapeptide ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Cyclic Hexapeptides ◽  
Aspergillus Sclerotiorum

Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC50 value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC50 values of 10.1 μM.

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