Active site studies of neurohypophyseal hormones. Comparison of oxytocin and arginine vasopressin analogs containing 2-D-tyrosine

1979 ◽  
Vol 101 (10) ◽  
pp. 2717-2721 ◽  
Author(s):  
Victor J. Hruby ◽  
Donald A. Upson ◽  
Diane M. Yamamoto ◽  
Clark W. Smith ◽  
Roderich Walter
Keyword(s):  
Arginine Vasopressin ◽  
Active Site ◽  
Neurohypophyseal Hormones

Active-site studies of neurohypophyseal hormones: synthesis and pharmacological properties of [5-(N4,N4-dimethylasparagine)]oxytocin

1979 ◽  
Vol 22 (7) ◽  
pp. 890-893 ◽  
Author(s):  
Roderich Walter ◽  
Glenn L. Stahl ◽  
Themistoeles Caplaneris ◽  
Paul Cordopatis ◽  
Dimitrios Theodoropoulos
Keyword(s):  
Active Site ◽  
Pharmacological Properties ◽  
Neurohypophyseal Hormones

Analogues of Neurohypophyseal Hormones, Oxytocin and Arginine Vasopressin, Conformationally Restricted in the N-Terminal Part of the Molecule

2006 ◽  
Vol 49 (6) ◽  
pp. 2016-2021 ◽  
Author(s):  
Wioleta Kowalczyk ◽  
Adam Prahl ◽  
Izabela Derdowska ◽  
Dariusz Sobolewski ◽  
Jadwiga Olejnik ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Terminal Part ◽  
Conformationally Restricted ◽  
Neurohypophyseal Hormones

2-O-methyl and 2-O-ethyl-tyrosine derivatives of [8-arginine]vasopressin analogs: Highly specific antidiuretic agonists

1988 ◽  
Vol 53 (11) ◽  
pp. 2617-2626 ◽  
Author(s):  
Krzysztof Bankowski ◽  
Bernard Lammek ◽  
Marian Kruszynski ◽  
Maurice Manning ◽  
Janny Seto ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Rat Uterus ◽  
Phase Synthesis ◽  
Neurohypophyseal Hormones ◽  
Tyrosine Derivatives ◽  
Activity Ratios ◽  
Treatment Of Diabetes ◽  
Derivatives Of

The solid phase synthesis of seven 2-O-methyl- and 2-O-ethyl-tyrosine substituted analogs of [8-arginine]vasopressin (AVP) with enhanced antidiuretic agonistic specificity is reported. These peptides are: [2-O-ethyltyrosine, 8-arginine]vasopressin (I), [2-O-methyltyrosine, 8-D-arginine]vasopressin (II), [2-O-ethyltyrosine, 8-D-arginine]vasopressin (III), [2-O-methyltyrosine, 4-valine, 8-arginine]vasopressin (IV), [2-O-ethyltyrosine, 4-valine, 8-arginine]vasopressin (V), [2-O-methyltyrosine, 4-valine, 8-D-arginine]vasopressin (VI), [2-O-ethyltyrosine, 4-valine, 8-D-arginine]vasopressin (VII). All analogs were tested for antidiuretic, antivasopressor and antioxytocic activities. Although all these new analogs are antidiuretic agonists they are antagonists of vasopressor responses to AVP, and of responses by the rat uterus to oxytocin. Thus, all seven new Tyr(Me) and Tyr(Et) containing analogs exhibit high antidiuretic specificity and have infinite antidiuretic/pressor (A/P) and antidiuretic/oxytocic (A/O) activity ratios. Some of these analogs e.g. Tyr(Me)DAVP, Tyr(Me)VAVP and Tyr(Me)VDAVP, which possess high antidiuretic activity with no pressor or oxytocic agonism, could be useful new pharmacological tools for characterizing receptors mediating specific responses to the neurohypophyseal hormones. They could also be potentially useful in the treatment of diabetes insipidus.

Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology

Endocrinology ◽  
2021 ◽  
Author(s):  
Ato O Aikins ◽  
Dianna H Nguyen ◽  
Obed Paundralingga ◽  
George E Farmer ◽  
Caroline Gusson Shimoura ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Indirect Effects ◽  
Cardiovascular Function ◽  
Neurosecretory Cells ◽  
Traditional View ◽  
Posterior Pituitary ◽  
Affiliative Behavior ◽  
Neurohypophyseal Hormones

Abstract Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.

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