Vapor phase hydrogen bonding of 2,2,2-trifluoroethanol with acetone

1976 ◽  
Vol 98 (20) ◽  
pp. 6109-6111 ◽  
Author(s):  
Edwin E. Tucker ◽  
Sherril D. Christian
Keyword(s):  
Hydrogen Bonding ◽  
Vapor Phase

Vapor-phase studies of hydrogen bonding in the trimethylamine-methanol system

1970 ◽  
Vol 9 (4) ◽  
pp. 839-843 ◽  
Author(s):  
Manfred Fild ◽  
Mary F. Swiniarski ◽  
Robert R. Holmes
Keyword(s):  
Hydrogen Bonding ◽  
Vapor Phase ◽  
Methanol System

A proton magnetic resonance estimate of the extent of intramolucular hydrogen bonding in derivatives of 2-trifluoromethyl phenol. Solvent effects

1976 ◽  
Vol 54 (14) ◽  
pp. 2243-2248 ◽  
Author(s):  
Ted Schaefer ◽  
J. Brian Rowbotham
Keyword(s):  
Free Energy ◽  
Hydrogen Bonding ◽  
Vapor Phase ◽  
Coupling Constants ◽  
Spin Coupling ◽  
Hydroxyl Group ◽  
Spin Coupling Constants ◽  
Hydroxyl Protons ◽  
Spin Spin Coupling ◽  
Derivatives Of

The long-range spin–spin coupling constants between hydroxyl protons and ring protons or fluorine nuclei are used to establish the conformer populations in iodine and brornine derivatives of 2-trifluoromethylphenol in C6H12, CCl4, and C6D6 solutions. The sequence Cl, [Formula: see text] is established for the so-called hydrogen bonding preferences of the hydroxyl group in 2,4,6-trisubstituted phenols, the corresponding free energy sequence being −ΔG = 1690, 1690 > 1300 > 1230 > 0 ± 200 cal/mol at 32 °C in CCl4 solution. An indirect estimate of the free energy differences in the vapor phase suggests the sequence −ΔG = 2800, 2800 > 2400 > 2300 > 1100 ± 300 cal/mol; the latter value meaning that the hydroxyl group in 4-bromo-2-trifluoromethylphenol prefers the CF3 group by this amount in the vapor phase. Benzene interacts preferentially with the OH group in this compound to the extent of 1300 cal/mol (ΔG), referenced to the vapor phase.

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