Synthetic studies on antitumor antibiotic, bleomycin. 27. Man-designed bleomycin with altered sequence specificity in DNA cleavage

1990 ◽  
Vol 112 (2) ◽  
pp. 838-845 ◽  
Author(s):  
Masami Otsuka ◽  
Takeshi Masuda ◽  
Andreas Haupt ◽  
Masaji Ohno ◽  
Takashi Shiraki ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Antitumor Antibiotic ◽  
Sequence Specificity ◽  
Synthetic Studies

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

Science ◽  
1984 ◽  
Vol 226 (4676) ◽  
pp. 843-844 ◽  
Author(s):  
L. Hurley ◽  
V. Reynolds ◽  
D. Swenson ◽  
G. Petzold ◽  
T. Scahill
Keyword(s):  
Dna Sequence ◽  
Dna Structure ◽  
Dna Adduct ◽  
Antitumor Antibiotic ◽  
Sequence Specificity ◽  
Dna Sequence Specificity

ChemInform Abstract: SYNTHETIC STUDIES ON AN ANTITUMOR ANTIBIOTIC, BLEOMYCIN. XIV. THE SYNTHESIS OF BOC-PYRIMIDOBLAMIC ACID

1985 ◽  
Vol 16 (31) ◽  
Author(s):  
M. OTSUKA ◽  
M. NARITA ◽  
M. YOSHIDA ◽  
S. KOBAYASHI ◽  
M. OHNO ◽  
...  
Keyword(s):  
Antitumor Antibiotic ◽  
Synthetic Studies

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

1994 ◽  
Vol 7 (3) ◽  
pp. 227-231 ◽  
Author(s):  
M. Palumbo ◽  
M. Mabilia ◽  
A. Pozzan ◽  
G. Capranico ◽  
S. Tinelli ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase Ii ◽  
Sequence Specificity ◽  
Topoisomerase Ii Inhibitors ◽  
Conformational Properties

Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

1976 ◽  
Vol 54 (16) ◽  
pp. 2563-2572 ◽  
Author(s):  
J. William Lown ◽  
Soo-Khoon Sim
Keyword(s):  
Antitumor Activity ◽  
Dna Cleavage ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Antitumor Antibiotics ◽  
Substitution Pattern ◽  
Circular Dna ◽  
Strand Scission ◽  
Independent Synthesis ◽  
Selective Catalysis

The syntheses of a group of 2-(o-nitrophenyl)- and 2-(o-aminophenyl)-5,8-quinolinediones which are structurally related to the antitumor antibiotic streptonigrin are described. Ambiguities in the position of required nucleophilic displacements are resolved by independent synthesis. The rates of single strand cleavage of PM2 ccc-DNA (covalently-closed circular-DNA) induced by these compounds are compared, which correlates with antitumor activity. The 2-(o-nitrophenyl) derivatives give consistently more rapid DNA cleavage than the 2-(o-aminophenyl) compounds. The autoxidations of the dihydroxyquinolines are subject to selective catalysis by Cu2+ on. 2-(o-Aminophenyl)-7-amino-6-methoxy-5,6-quinolinedione which has a substitution pattern most closely resembling streptonigrin also closely parallels the rate of scission of DNA of the latter in the presence of NADPH.

ChemInform Abstract: UCE1022, a New Antitumor Antibiotic with Topoisomerase I Mediated DNA Cleavage Activity, from Paecilomyces.

ChemInform ◽  
2010 ◽  
Vol 26 (11) ◽  
pp. no-no
Author(s):  
N. FUJII ◽  
Y. YAMASHITA ◽  
K. ANDO ◽  
T. AGATSUMA ◽  
Y. SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals UCE6, A new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from actinomycetes.

1993 ◽  
Vol 46 (7) ◽  
pp. 1173-1174 ◽  
Author(s):  
NOBORU FUJII ◽  
YOSHINORI YAMASHITA ◽  
SHIGERU CHIBA ◽  
YOUICHI UOSAKI ◽  
YUTAKA SAITOH ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Antitumor Antibiotic ◽  
Cleavage Activity ◽  
Dna Cleavage Activity
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