Analysis of the Enol Ether Transfer Catalyzed by UDP-GlcNAc Enolpyruvyl Transferase Using (E)- and (Z)-Isomers of Phosphoenolbutyrate: Stereochemical, Partitioning, and Isotope Effect Studies

1995 ◽  
Vol 117 (28) ◽  
pp. 7329-7337 ◽  
Author(s):  
Watson J. Lees ◽  
Christopher T. Walsh
Keyword(s):  
Isotope Effect ◽  
Enol Ether ◽  
E And Z Isomers ◽  
Ether Transfer

scholarly journals Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B

2016 ◽  
Vol 14 (26) ◽  
pp. 6289-6296 ◽  
Author(s):  
Pranab K. Bhadra ◽  
Abdolreza Hassanzadeh ◽  
Biljana Arsic ◽  
David G. Allison ◽  
Gareth A. Morris ◽  
...  
Keyword(s):  
Isotope Effect ◽  
Efficient Synthesis ◽  
Enol Ether ◽  
Deuterium Isotope Effect

An efficient synthesis of 8-d-erythromycin B was achieved. A deuterium isotope effect suppresses formation of the corresponding enol ether, which may result in reduced gut-motilide effects.

The isotope effect in electronic expectation values: an all-quantum study of C6H6 and C6D6

1998 ◽  
Vol 93 (5) ◽  
pp. 801-807
Author(s):  
JOACHIM SCHULTE ◽  
MICHAEL BOHM ◽  
RAFAEL RAMIREZ
Keyword(s):  
Isotope Effect ◽  
Expectation Values

Isotope effect in the organic superconductor βH-(BEDT-TTF)2I3 where BEDT-TTF is bis (ethylenedithiotetrathiafulvalene)

1993 ◽  
Vol 3 (3) ◽  
pp. 871-885 ◽  
Author(s):  
P. Auban-Senzier ◽  
C. Bourbonnais ◽  
D. Jérome ◽  
C. Lenoir ◽  
P. Batail ◽  
...  
Keyword(s):  
Isotope Effect ◽  
Organic Superconductor

Stereodivergent Alkyne Hydrofluorination Using a Simple Practical Reagent

2020 ◽  
Author(s):  
Rui Guo ◽  
Xiaotian Qi ◽  
Hengye Xiang ◽  
Paul Geaneoates ◽  
Ruihan Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Biologically Active ◽  
Dft Studies ◽  
Thermodynamic Control ◽  
Important Goal ◽  
Peptide Bonds ◽  
Metal Free ◽  
Vinyl Cation ◽  
E And Z Isomers ◽  
Vinyl Fluorides

Vinyl fluorides play an important role in drug development as they serve as bioisosteres for peptide bonds and are found in a range of biologically active molecules. The discovery of safe, general and practical procedures to prepare vinyl fluorides remains an important goal and challenge for synthetic chemistry. Here we introduce an inexpensive and easily-handled reagent and report simple, scalable, and metal-free protocols for the regioselective and stereodivergent hydrofluorination of alkynes to access both the E and Z isomers of vinyl fluorides. These conditions were suitable for a diverse collection of alkynes, including several highly-functionalized pharmaceutical derivatives. Mechanistic and DFT studies support C–F bond formation through a vinyl cation intermediate, with the (E)- and (Z)-hydrofluorination products forming under kinetic and thermodynamic control, respectively.<br>

Anharmonic Coupling Revealed by the Vibrational Spectra of Solvated Protonated Methanol: Fermi Resonance, Combination Bands, and Isotope Effect

2021 ◽  
Vol 125 (9) ◽  
pp. 1910-1918
Author(s):  
Chih-Kai Lin ◽  
Qian-Rui Huang ◽  
Ying-Cheng Li ◽  
Ha-Quyen Nguyen ◽  
Jer-Lai Kuo ◽  
...  
Keyword(s):  
Isotope Effect ◽  
Vibrational Spectra ◽  
Fermi Resonance ◽  
Anharmonic Coupling ◽  
Combination Bands
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