scholarly journals Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B

2016 ◽  
Vol 14 (26) ◽  
pp. 6289-6296 ◽  
Author(s):  
Pranab K. Bhadra ◽  
Abdolreza Hassanzadeh ◽  
Biljana Arsic ◽  
David G. Allison ◽  
Gareth A. Morris ◽  
...  
Keyword(s):  
Isotope Effect ◽  
Efficient Synthesis ◽  
Enol Ether ◽  
Deuterium Isotope Effect

An efficient synthesis of 8-d-erythromycin B was achieved. A deuterium isotope effect suppresses formation of the corresponding enol ether, which may result in reduced gut-motilide effects.

Partial kinetic ‘resolution’ resulting from a deuterium isotope effect

1991 ◽  
Vol 0 (12) ◽  
pp. 801-802 ◽  
Author(s):  
Panayiotis Anastasis ◽  
Raymond Duffin ◽  
Christopher Gilmore ◽  
Karl Overton
Keyword(s):  
Isotope Effect ◽  
Kinetic Resolution ◽  
Deuterium Isotope Effect

Deuterium isotope effect in the interaction of N-nitrosodimethylamine, ethanol, and related compounds with cytochrome P-450IIE1

1991 ◽  
Vol 4 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Chung S. Yang ◽  
Hiroyuki Ishizaki ◽  
Maojung Lee ◽  
Addi Fadel ◽  
David Wade
Keyword(s):  
Isotope Effect ◽  
Deuterium Isotope Effect ◽  
Related Compounds
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