Design and Synthesis of a New Peptide Recognizing a Specific 16-Base-Pair Site of DNA

1995 ◽  
Vol 117 (23) ◽  
pp. 6287-6291 ◽  
Author(s):  
Changmoon Park ◽  
Judy L. Campbell ◽  
William A. Goddard
Keyword(s):  
Base Pair ◽  
Design And Synthesis

scholarly journals Total Synthesis of a Functional Designer Eukaryotic Chromosome

Science ◽  
2014 ◽  
Vol 344 (6179) ◽  
pp. 55-58 ◽  
Author(s):  
Narayana Annaluru ◽  
Héloïse Muller ◽  
Leslie A. Mitchell ◽  
Sivaprakash Ramalingam ◽  
Giovanni Stracquadanio ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Base Pair ◽  
Stop Codon ◽  
Bacterial Genomes ◽  
Transfer Rnas ◽  
Eukaryotic Chromosome ◽  
Design And Synthesis ◽  
Biochemical Pathways ◽  
Chromosome Iii ◽  
Subtelomeric Regions

Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871–base pair designer eukaryotic chromosome, synIII, which is based on the 316,617–base pair native Saccharomyces cerevisiae chromosome III. Changes to synIII include TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites to enable genome scrambling. SynIII is functional in S. cerevisiae. Scrambling of the chromosome in a heterozygous diploid reveals a large increase in a-mater derivatives resulting from loss of the MATα allele on synIII. The complete design and synthesis of synIII establishes S. cerevisiae as the basis for designer eukaryotic genome biology.

ChemInform Abstract: Design and Synthesis of Heterocyclic Cations for Specific DNA Recognition: From AT-Rich to Mixed-Base-Pair DNA Sequences.

ChemInform ◽  
2014 ◽  
Vol 45 (29) ◽  
pp. no-no
Author(s):  
Yun Chai ◽  
Ananya Paul ◽  
Michael Rettig ◽  
W. David Wilson ◽  
David W. Boykin
Keyword(s):  
Dna Sequences ◽  
Base Pair ◽  
Dna Recognition ◽  
Design And Synthesis ◽  
Heterocyclic Cations

Design and synthesis of solid state structures with conjugate acid–base pair interactions

CrystEngComm ◽  
2012 ◽  
Vol 14 (11) ◽  
pp. 3851 ◽  
Author(s):  
Sathyanarayana Reddy Perumalla ◽  
Changquan Calvin Sun
Keyword(s):  
Solid State ◽  
Base Pair ◽  
Acid Base ◽  
Design And Synthesis ◽  
Conjugate Acid ◽  
Solid State Structures ◽  
Pair Interactions

Design and synthesis of a novel fluorescent benzo[g]imidazo[4,5-c]quinoline nucleoside for monitoring base-pair-induced protonation with cytosine: distinguishing cytosine via changes in the intensity and wavelength of fluorescence

2016 ◽  
Vol 14 (16) ◽  
pp. 3934-3942 ◽  
Author(s):  
Shogo Siraiwa ◽  
Azusa Suzuki ◽  
Ryuzi Katoh ◽  
Yoshio Saito
Keyword(s):  
Base Pair ◽  
Pair Formation ◽  
Design And Synthesis

A novel fluorescent benzo[g]imidazo[4,5-c]quinoline nucleoside BIQA was developed and used to monitor BIQA–C base-pair formation in ODN duplexes.

scholarly journals Design and Synthesis of Heterocyclic Cations for Specific DNA Recognition: From AT-Rich to Mixed-Base-Pair DNA Sequences

2014 ◽  
Vol 79 (3) ◽  
pp. 852-866 ◽  
Author(s):  
Yun Chai ◽  
Ananya Paul ◽  
Michael Rettig ◽  
W. David Wilson ◽  
David W. Boykin
Keyword(s):  
Dna Sequences ◽  
Base Pair ◽  
Dna Recognition ◽  
Design And Synthesis ◽  
Heterocyclic Cations

scholarly journals Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21390-21396
Author(s):  
Ryotaro Notomi ◽  
Lei Wang ◽  
Shigeki Sasaki ◽  
Yosuke Taniguchi
Keyword(s):  
Base Pair ◽  
Purine Nucleoside ◽  
Nucleoside Analogues ◽  
Triplex Dna ◽  
Duplex Dna ◽  
Design And Synthesis ◽  
Direct Recognition ◽  
First Time ◽  
Parallel Type

We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

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