Aristolochene Synthase. Mechanism-Based Inhibition of a Terpenoid Cyclase

David E. Cane; Clifford Bryant

doi:10.1021/ja00105a061

Aristolochene Synthase. Mechanism-Based Inhibition of a Terpenoid Cyclase

Journal of the American Chemical Society ◽

10.1021/ja00105a061 ◽

1994 ◽

Vol 116 (26) ◽

pp. 12063-12064 ◽

Cited By ~ 16

Author(s):

David E. Cane ◽

Clifford Bryant

Keyword(s):

Aristolochene Synthase ◽

Terpenoid Cyclase

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Faculty Opinions recommendation of Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725442771.793512383 ◽

2015 ◽

Author(s):

Jon Thorson

Keyword(s):

Farnesyl Diphosphate ◽

Aristolochene Synthase

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Evidence for Differential Folding of Farnesyl Pyrophosphate in the Active Site of Aristolochene Synthase: A Single-Point Mutation Converts Aristolochene Synthase into an (E)-β-Farnesene Synthase†

Biochemistry ◽

10.1021/bi034410m ◽

2003 ◽

Vol 42 (25) ◽

pp. 7741-7747 ◽

Cited By ~ 44

Author(s):

Athina Deligeorgopoulou ◽

Rudolf K. Allemann

Keyword(s):

Point Mutation ◽

Active Site ◽

Single Point ◽

Single Point Mutation ◽

Farnesyl Pyrophosphate ◽

Aristolochene Synthase

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6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase

Organic & Biomolecular Chemistry ◽

10.1039/b817194g ◽

2009 ◽

Vol 7 (5) ◽

pp. 962 ◽

Cited By ~ 27

Author(s):

David J. Miller ◽

Fanglei Yu ◽

David W. Knight ◽

Rudolf K. Allemann

Keyword(s):

Farnesyl Diphosphate ◽

Aristolochene Synthase

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Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis

Current Opinion in Structural Biology ◽

10.1016/j.sbi.2016.05.010 ◽

2016 ◽

Vol 41 ◽

pp. 27-37 ◽

Cited By ~ 16

Author(s):

Mengbin Chen ◽

Golda G Harris ◽

Travis A Pemberton ◽

David W Christianson

Keyword(s):

Bifunctional Catalysis ◽

Terpenoid Cyclase

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The role of aristolochene synthase in diphosphate activation

Chemical Communications ◽

10.1039/c2cc17588f ◽

2012 ◽

Vol 48 (26) ◽

pp. 3230 ◽

Cited By ~ 13

Author(s):

Juan A. Faraldos ◽

Veronica Gonzalez ◽

Rudolf K. Allemann

Keyword(s):

Aristolochene Synthase

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Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysisElectronic Supplementary Information (ESI) available: GC profiles of co-injections of germacrene A from ASW334F and ASW334V with authentic germacrene A; mass spectra of germacrene A produced by ASW334V and of an authentic sample; mass spectra of valencene produced by ASW334F and of an authentic sample. See http://www.rsc.org/suppdata/cc/b3/b306867f/

Chemical Communications ◽

10.1039/b306867f ◽

2003 ◽

pp. 2162 ◽

Cited By ~ 27

Author(s):

Athina Deligeorgopoulou ◽

Susan E. Taylor ◽

Silvia Forcat ◽

Rudolf K. Allemann

Keyword(s):

Mass Spectra ◽

Authentic Sample ◽

Supplementary Information ◽

Sample Mass ◽

Aristolochene Synthase

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Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase

ACS Chemical Biology ◽

10.1021/acschembio.5b00145 ◽

2015 ◽

Vol 10 (7) ◽

pp. 1729-1736 ◽

Cited By ~ 21

Author(s):

Kathleen A. Rising ◽

Charisse M. Crenshaw ◽

Hyun Jo Koo ◽

Thangaiah Subramanian ◽

Kareem A. H. Chehade ◽

...

Keyword(s):

Farnesyl Diphosphate ◽

Aristolochene Synthase

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Inhibition of (+)-Aristolochene Synthase with Iminium Salts Resembling Eudesmane Cation

Organic Letters ◽

10.1021/ol2000843 ◽

2011 ◽

Vol 13 (5) ◽

pp. 1202-1205 ◽

Cited By ~ 18

Author(s):

Juan A. Faraldos ◽

Rudolf K. Allemann

Keyword(s):

Iminium Salts ◽

Aristolochene Synthase

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Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphateElectronic supplementary information (ESI) available: GC-profiles of co-injections of 4 from ASY92V and authentic material and mass spectra of 4 produced by ASY92V and an authentic sample. See http://www.rsc.org/suppdata/cc/b2/b206517g/

Chemical Communications ◽

10.1039/b206517g ◽

2002 ◽

pp. 2384-2385 ◽

Cited By ~ 23

Author(s):

Melanie J. Calvert ◽

Susan E. Taylor ◽

Rudolf K. Allemann

Keyword(s):

Mass Spectra ◽

Authentic Sample ◽

Supplementary Information ◽

Authentic Material ◽

Aristolochene Synthase

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Pentalenene Synthase. Purification, Molecular Cloning, Sequencing, and High-Level Expression in Escherichia coli of a Terpenoid Cyclase from Streptomyces UC5319

Biochemistry ◽

10.1021/bi00185a024 ◽

1994 ◽

Vol 33 (19) ◽

pp. 5846-5857 ◽

Cited By ~ 104

Author(s):

David E. Cane ◽

Jae-Kyung Sohng ◽

Carol R. Lamberson ◽

Suzanne M. Rudnicki ◽

Zhen Wu ◽

...

Keyword(s):

Escherichia Coli ◽

Molecular Cloning ◽

High Level Expression ◽

Expression In Escherichia Coli ◽

Pentalenene Synthase ◽

High Level ◽

Terpenoid Cyclase

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