Design, synthesis, and complexing properties of (1Cys-1'Cys,4Cys-4'Cys)-dithiobis(Ac-L-1Cys-L-Pro-D-Val-L-4Cys-NH2). The first example of a new family of ion-binding peptides

1993 ◽  
Vol 115 (25) ◽  
pp. 11663-11670 ◽  
Author(s):  
Carlos Garcia-Echeverria ◽  
Fernando Albericio ◽  
Ernest Giralt ◽  
Miquel Pons
Keyword(s):  
Ion Binding ◽  
Design Synthesis ◽  
New Family ◽  
Binding Peptides ◽  
Complexing Properties

Intracellular mineralization of gold nanoparticles using gold ion-binding peptides with cell-penetrating ability

2021 ◽  
Author(s):  
Makoto Ozaki ◽  
Shuhei Yoshida ◽  
Takaaki Tsuruoka ◽  
Kenji Usui
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanostructures ◽  
Ion Binding ◽  
Cell Penetrating ◽  
Binding Peptides ◽  
Conventional Methods ◽  
Gold Ion

Our method can produce uniquely shaped gold nanostructures in lower HAuCl4 concentration than conventional methods by intracellular functions using peptide assembled structures as a template.

Development of Metal Ion Binding Peptides Using Phage Surface Display Technology

2017 ◽  
Vol 262 ◽  
pp. 591-595 ◽  
Author(s):  
Nora Schönberger ◽  
Sabine Matys ◽  
Katrin Flemming ◽  
Falk Lehmann ◽  
Franziska L. Lederer ◽  
...  
Keyword(s):  
Metal Ion ◽  
Specific Binding ◽  
Surface Display ◽  
Ionic Species ◽  
Phage Display Library ◽  
Complexing Agents ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Display Technology ◽  
Binding Peptides

Phage surface display technology is a useful tool for the identification of biosorptive peptides. In this work it is used for the identification of cobalt, nickel and gallium binding peptides. We present methods for the enrichment of metal ion binding bacteriophage clones from a commercial phage display library. Metal ion selective peptides are suitable to separate as well as concentrate cobalt and nickel from copper black shale leaching products (EcoMetals project) and gallium from industrial waste waters (EcoGaIn project). In contrast to common capture methods of specific binding phage for solid materials the ionic species have to be immobilized prior to the bio-panning procedure. This was realized by chemical complexation of the metal ions using commercial complexing agents on porous matrices. Moreover, an option to harvest non elutable strong binding phage is proposed.

A new family of heavy transition metal coordination compounds and its application, I. Design, synthesis and characterization of volatile organohafnium precursors

1995 ◽  
Vol 9 (3) ◽  
pp. 259-266 ◽  
Author(s):  
Andrei V. Grafov ◽  
Eugene A. Mazurenko ◽  
Giovanni A. Battiston ◽  
Pierino Zanella ◽  
Francesco Tisato ◽  
...  
Keyword(s):  
Transition Metal ◽  
Coordination Compounds ◽  
Metal Coordination ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
New Family

scholarly journals Tunable Hydrophobicity in DNA Micelles: Design, Synthesis, and Characterization of a New Family of DNA Amphiphiles

2010 ◽  
Vol 16 (43) ◽  
pp. 12852-12859 ◽  
Author(s):  
Milena Anaya ◽  
Minseok Kwak ◽  
Andrew J. Musser ◽  
Klaus Müllen ◽  
Andreas Herrmann
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
New Family

Design, synthesis, and comparison of crystal, solution, and calculated structures within a new family of cavitands

1988 ◽  
pp. 407 ◽  
Author(s):  
Donald J. Cram ◽  
Jean Weiss ◽  
Roger C. Helgeson ◽  
Carolyn B. Knobler ◽  
Andrea E. Dorigo ◽  
...  
Keyword(s):  
Design Synthesis ◽  
New Family

scholarly journals 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3897
Author(s):  
David Ramírez ◽  
Melissa Mejia-Gutierrez ◽  
Braulio Insuasty ◽  
Susanne Rinné ◽  
Aytug K. Kiper ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Rational Design ◽  
Experimental Studies ◽  
Input Resistance ◽  
Cell Types ◽  
Imaging Plate ◽  
Channel Blockers ◽  
Design Synthesis ◽  
New Family ◽  
Channel Inhibition

TASK channels belong to the two-pore-domain potassium (K2P) channels subfamily. These channels modulate cellular excitability, input resistance, and response to synaptic stimulation. TASK-channel inhibition led to membrane depolarization. TASK-3 is expressed in different cancer cell types and neurons. Thus, the discovery of novel TASK-3 inhibitors makes these bioactive compounds very appealing to explore new cancer and neurological therapies. TASK-3 channel blockers are very limited to date, and only a few heterofused compounds have been reported in the literature. In this article, we combined a pharmacophore hypothesis with molecular docking to address for the first time the rational design, synthesis, and evaluation of 5-(indol-2-yl)pyrazolo[3,4-b]pyridines as a novel family of human TASK-3 channel blockers. Representative compounds of the synthesized library were assessed against TASK-3 using Fluorometric imaging plate reader—Membrane Potential assay (FMP). Inhibitory properties were validated using two-electrode voltage-clamp (TEVC) methods. We identified one active hit compound (MM-3b) with our systematic pipeline, exhibiting an IC50 ≈ 30 μM. Molecular docking models suggest that compound MM-3b binds to TASK-3 at the bottom of the selectivity filter in the central cavity, similar to other described TASK-3 blockers such as A1899 and PK-THPP. Our in silico and experimental studies provide a new tool to predict and design novel TASK-3 channel blockers.

scholarly journals Structure–activity relationship for the solid state emission of a new family of “push–pull” π-extended chromophores

2017 ◽  
Vol 196 ◽  
pp. 143-161 ◽  
Author(s):  
Andrea Nitti ◽  
Francesca Villafiorita-Monteleone ◽  
Aurora Pacini ◽  
Chiara Botta ◽  
Tersilla Virgili ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Optical Properties ◽  
Solid State ◽  
Substituted Benzenes ◽  
Design Synthesis ◽  
Structure Building ◽  
New Family ◽  
Structure Activity ◽  
Comprehensive Picture ◽  
Cyano Groups

We report the design, synthesis, molecular optical properties, and solid state emissive behaviour of a series of novel compounds, which, similar to the archetypal AIE luminogen tetraphenylethene, are formed of a central olefin stator and decorated with either three or four rotors. These rotors, being either electron-rich substituted benzenes, or electron-withdrawing functional groups (esters, ketones, cyano groups) confer a “push–pull” character to the overall molecular structure. Building on both new and already published contributions, a comprehensive picture of the properties and the potential of these compounds is provided.

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