Synthesis of conjugated polyene carbonyl derivatives of nitroxyl spin-labels and determination of their molecular structure and conformation by electron nuclear double resonance

1993 ◽  
Vol 115 (9) ◽  
pp. 3674-3682 ◽  
Author(s):  
Devkumar Mustafi ◽  
William E. Boisvert ◽  
Marvin W. Makinen
Keyword(s):  
Molecular Structure ◽  
Double Resonance ◽  
Spin Labels ◽  
Electron Nuclear Double Resonance ◽  
Carbonyl Derivatives ◽  
Derivatives Of

Determination of the g-matrix orientation in flavin radicals by high-field/high-frequency electron-nuclear double resonance

2005 ◽  
Vol 43 (S1) ◽  
pp. S96-S102 ◽  
Author(s):  
Christopher W. M. Kay ◽  
Erik Schleicher ◽  
Kenichi Hitomi ◽  
Takeshi Todo ◽  
Robert Bittl ◽  
...  
Keyword(s):  
High Frequency ◽  
High Field ◽  
Double Resonance ◽  
Electron Nuclear Double Resonance ◽  
Matrix Orientation

Electron-Nuclear Double-Resonance Determination of theC13andH1Hyperfine Tensors for Polyacetylene

1983 ◽  
Vol 50 (7) ◽  
pp. 533-536 ◽  
Author(s):  
H. Thomann ◽  
L. R. Dalton ◽  
Y. Tomkiewicz ◽  
N. S. Shiren ◽  
T. C. Clarke
Keyword(s):  
Double Resonance ◽  
Electron Nuclear Double Resonance

scholarly journals The Reactive Carbonyl Derivatives of Proteins, Methylglyoxal, and Malondialdehyde in Blood of Women with Breast Cancer

2021 ◽  
Vol 9 (B) ◽  
pp. 509-514
Author(s):  
Sabina Zhumakayeva ◽  
Larissa Muravlyova ◽  
Valentina Sirota ◽  
Vilen Molotov-Luchansky ◽  
Ryszhan Bakirova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Pathological Process ◽  
Carbonyl Derivatives ◽  
Mechanisms Of Carcinogenesis ◽  
High Cytotoxicity ◽  
Derivatives Of ◽  
Sensitive Marker ◽  
Literature Data Analysis

BACKGROUND: Every year 1.5 million women in the world are diagnosed with breast cancer (BC). In 2018, more than 260,000 new cases of cancer and more than 40,000 deaths due to this disease were detected. At the same time, in Kazakhstan, an intensive indicator of the incidences of BC in 2018 amounted to 25.3% per population of 100 thousand people (2017–24.5%) with a growth rate of 3.1%, which in absolute numbers are 4,648 new cases per year. In terms of mortality, BC ranks third after lung and stomach cancer (6.8%). AIM: This necessitates a detailed study of the molecular mechanisms that underlie the development and progression of BC. One of the mechanisms of carcinogenesis is oxidative stress (OS). An increase in malondialdehyde (MDA) levels was detected in the early stages of cancer. It was suggested that MDA, due to its high cytotoxicity, acts as a promoter of the tumor and cocarcinogen agent. METHODS: Therefore, violation of the parameters of OS in BC is in no doubt. However, according to the literature data analysis, these results are ambiguous and contradictory. There are no studies on a comprehensive assessment of the oxidative destruction of lipids, proteins, and nucleic acids in BC. CONCLUSION: The nature and direction of changes in various components of OS in patients with BC have not been adequately studied, which is necessary for a correct assessment of the involvement of OS in the mechanism of the pathological process and determination of a sensitive marker of the risk of BC or its progression.

Determination of dipole moment values of anisotropic molecules using Brot's formalism

1990 ◽  
Vol 68 (9) ◽  
pp. 1523-1526
Author(s):  
P. Brito ◽  
M. Mechetti
Keyword(s):  
Molecular Structure ◽  
Dipole Moment ◽  
Dipole Moments ◽  
Dilute Solutions ◽  
Molecular Anisotropy ◽  
Derivatives Of ◽  
Best Parameters

A method for the determination of dipole moment values based on Brot's theory is proposed. It takes into account the influence of the molecular anisotropies of shape and polarizability on the permittivity of a mixture. Starting from measurements performed on dilute solutions and from the knowledge of the molecular structure of some chlorinated derivatives of α-cyanostilbene and 1,3 derivatives of benzene, the best parameters of an ellipsoid used for the representation of a polar anisotropic molecule are determined. The dipole moments obtained, using benzene and tetrachloromethane as solvents, are finally compared to values from the literature. Keywords: dipole moment, Brot's formalism, molecular anisotropy.

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