Kinetics of the oxidation of cerium(III) by peroxysulfuric acids induced by cobalt-60 .gamma. radiation

1970 ◽  
Vol 74 (12) ◽  
pp. 2475-2479 ◽  
Author(s):  
Ralph W. Matthews ◽  
Harvey A. Mahlman ◽  
Thomas J. Sworski
Keyword(s):  
1961 ◽  
Vol 7 (2) ◽  
pp. 135-139 ◽  
Author(s):  
John R. Polley

The use of gamma radiation from a cobalt-60 cell for the preparation of non-infective diagnostic antigens for influenza A, influenza B, mumps, smallpox, and herpes simplex has been investigated. It was found possible to destroy the infectivity while retaining most of the complement-fixing activity of all these antigens. The degree of purity of the antigen had no apparent effect on the rate of inactivation, as is the case when formaldehyde is used. Under the experimental conditions described, the degree of inactivation depended on the total amount of radiation applied and not on the dose rate. The kinetics of virus inactivation make it possible to calculate the amount of radiation required to destroy infectivity completely and yet retain most of the antigenicity. If necessary it is possible to apply an additional calculated amount of radiation to destroy residual infectivity without causing loss of antigenicity. Gamma radiation appears to be superior to formaldehyde treatment for the preparation of the herpes simplex antigen which is particularly sensitive to heat and to formaldehyde.


Author(s):  
I. P. Kim ◽  
I. I. Migunova ◽  
T. K. Ionina ◽  
V. S. Ivanov ◽  
I. M. Barkalov

1997 ◽  
Vol 83 (6) ◽  
pp. 1119 ◽  
Author(s):  
Carmen Nasarre ◽  
U. R. Rao ◽  
Sharon U. Coleman ◽  
Thomas R. Klei

1968 ◽  
Vol 6 (11) ◽  
pp. 3127-3137 ◽  
Author(s):  
Fujio Suganuma ◽  
Hiroshi Mitsui ◽  
Sueo Machi ◽  
Miyki Hagiwara ◽  
Tsutomu Kagiya

2002 ◽  
Vol 49 (1) ◽  
pp. 205-210 ◽  
Author(s):  
Tomasz Kryczka ◽  
Maciej Bero ◽  
Janusz Kasperczyk ◽  
Piotr Dobrzyński ◽  
Barbara Marciniec ◽  
...  

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.


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