Investigation of the .beta.-cyclodextrin-indole inclusion complex by absorption and fluorescence spectroscopies

1987 ◽  
Vol 91 (11) ◽  
pp. 2739-2745 ◽  
Author(s):  
Aydin. Orstan ◽  
J. B. Alexander. Ross
Keyword(s):  
Inclusion Complex ◽  
Beta Cyclodextrin

An Assessment of Olmesartan Medoxomil Tablet by Inclusion Complex Technique

2021 ◽  
pp. 193-197
Author(s):  
Deepak Sarangi ◽  
Subhashree Mallick ◽  
Anjum Ara ◽  
Sanjeeb Kumar Sahoo ◽  
Rabinarayan Rana
Keyword(s):  
Inclusion Complex ◽  
Water Solubility ◽  
Olmesartan Medoxomil ◽  
Complexing Agents ◽  
Complexing Agent ◽  
Angiotensin Ii Receptor ◽  
Current Effort ◽  
Ir Studies ◽  
Beta Cyclodextrin ◽  
Ft Ir

Olmesartan Medoxomil is an AT1 subtype selected angiotensin-II receptor antagonist approved for the treatment of hypertension. It has low water solubility, so the current effort is being made to enhance the solubility of the Olmesartan by inclusion complex and to incorporate them into tablets by direct compression. Complexing agent like Beta cyclodextrin and polyvinyalpyrrolidone has been used for complexation method. FT-IR studies have shown that there is no link between drugs and complexing agents. Among all methods, the inclusion complex (OLBCD 3) containing the drug: Beta cyclodextrin in a 1: 3 ratio showed rapid drug release (87.41% within 30 minutes) and post compression parameters are within limits. All the values obtained from pre compression and post compression parameters meets the legal requirements for tablets. Stability studies of batch no OLBCD 3 shows no significant change. Therefore, it can be concluded that the structure was stable.

scholarly journals Inclusion complex of acetohexamide with .BETA.-cyclodextrin and its hypoglycemic activity in rabbit.

1979 ◽  
Vol 27 (2) ◽  
pp. 398-402 ◽  
Author(s):  
KANETO UEKAMA ◽  
NAOKI MATSUO ◽  
FUMITOSHI HIRAYAMA ◽  
TATSUYA YAMAGUCHI ◽  
YORISHIGE IMAMURA ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Hypoglycemic Activity ◽  
Beta Cyclodextrin

Preparation, characterization and molecular modeling studies of the inclusion complex of Caffeine with Beta-cyclodextrin

2015 ◽  
Vol 1099 ◽  
pp. 616-624 ◽  
Author(s):  
Samikannu Prabu ◽  
Meenakshisundaram Swaminathan ◽  
Krishnamoorthy Sivakumar ◽  
Rajaram Rajamohan
Keyword(s):  
Molecular Modeling ◽  
Inclusion Complex ◽  
Beta Cyclodextrin ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry

2021 ◽  
Vol 17 ◽  
Author(s):  
Ping Yang ◽  
Jinhua Luo ◽  
Shuo Yan ◽  
Xiaohong Li ◽  
Qian Yao
Keyword(s):  
Small Intestine ◽  
Inclusion Complex ◽  
Host Molecules ◽  
Beta Cyclodextrin ◽  
Mouse Small Intestine ◽  
Ft Ir ◽  
Hydroxypropyl Beta Cyclodextrin ◽  
Assay Conditions

Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear. Objective: In this study, oleuropein (OL) inclusion complex employing hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD. Methods: The assay conditions were optimized to augment the method sensitivity. Molecular docking was employed to verify the strong interaction between PP and HP-beta-CD. The permeation process of free HP-beta-CD, HP-beta-CD of OL inclusion complex, free OL, and OL in the inclusion complex, was examined, respectively, using an in vitro mouse small intestine model. Results: Though HP-beta-CD possessed hydrophilic outside shell, it could permeate through mouse small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine. Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98).

Anticryptosporidial Activity of Furan Derivative G1 and Its Inclusion Complex with Beta-Cyclodextrin

2004 ◽  
Vol 93 (1) ◽  
pp. 197-206 ◽  
Author(s):  
J.A. Castro‐Hermida ◽  
H. GóMez‐Couso ◽  
M.E. Ares‐Mazás ◽  
M.M. Gonzalez‐Bedia ◽  
N. CastañEda‐Cancio ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Furan Derivative ◽  
Beta Cyclodextrin
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