scholarly journals Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo

Molecules ◽  
2017 ◽  
Vol 22 (9) ◽  
pp. 1513 ◽  
Author(s):  
Sun-Jung Yoon ◽  
Hoon Hyun ◽  
Deok-Won Lee ◽  
Dae Yang
Keyword(s):  
Wound Healing ◽  
Inclusion Complex ◽  
Visible Light ◽  
Glycol Chitosan ◽  
Chitosan Hydrogel ◽  
Beta Cyclodextrin

scholarly journals β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

2021 ◽  
Vol 22 (2) ◽  
pp. 700
Author(s):  
Young Jae Moon ◽  
Sun-Jung Yoon ◽  
Jeung-Hyun Koo ◽  
Yihyun Yoon ◽  
Hye Jun Byun ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bacterial Infection ◽  
Visible Light ◽  
Visible Light Irradiation ◽  
Light Irradiation ◽  
Tissue Adhesive ◽  
Proton Nuclear Magnetic Resonance ◽  
Scanning Calorimetry ◽  
Glycol Chitosan

Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (1H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.

Eugenol-acacia gum-based bifunctional nanofibers as a potent antifungal transdermal substitute

Nanomedicine ◽  
2021 ◽  
Author(s):  
Payal Gupta ◽  
Purusottam Mishra ◽  
Lalita Mehra ◽  
Kartikey Rastogi ◽  
Ramasare Prasad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inclusion Complex ◽  
Polyvinyl Alcohol ◽  
Rat Model ◽  
Candida Species ◽  
Antibiofilm Activity ◽  
Acacia Gum ◽  
Rat Experiments ◽  
Wound Healing Activity

Aim: Fungal biofilms interfere with the wound healing processes. Henceforth, the study aims to fabricate a biomaterial-based nano-scaffold with the dual functionalities of wound healing and antibiofilm activity. Methods: Nanofibers comprising acacia gum, polyvinyl alcohol and inclusion complex of eugenol in β-cyclodextrin (EG-NF) were synthesized using electrospinning. Antibiofilm studies were performed on Candida species, and the wound-healing activity was evaluated through an in vivo excision wound rat model. Results: The EG-NF potentially eradicated the mature biofilm of Candida species and their clinical isolates. Further, EG-NF also enhanced the re-epithelization and speed of wound healing in in vivo rat experiments. Conclusion: The study established the bifunctional applications of eugenol nanofibers as a transdermal substitute with antifungal potency.

scholarly journals Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2270
Author(s):  
Longhao Jin ◽  
Kyeongsoon Park ◽  
Yihyun Yoon ◽  
Hyeon Soo Kim ◽  
Hyeon Ji Kim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Visible Light ◽  
Wound Dressing ◽  
Wound Dressings ◽  
Animal Testing ◽  
Normal Wound Healing ◽  
Collagen Hydrogel ◽  
Vis Spectroscopy ◽  
Clinical Potential

Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The 1H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two material types. In addition, ultraviolet–visible (UV–vis) spectroscopy proved an inclusion complex formation between HP-β-CD and TCS, judging by a unique peak observed at 280 cm−1. Furthermore, ColMA/CD-ic-TCS exhibited an interconnected porous structure, controlled release of TCS, good biocompatibility, and antibacterial activity. By in vivo animal testing, we found that ColMA/CD-ic-TCS had a superior wound healing capacity, compared to the other hydrocolloids evaluated, due to synergistic interaction between ColMA and CD-ic-TCS. Together, our findings indicate that ColMA/CD-ic-TCS has a clinical potential as an antibacterial wound dressing.

scholarly journals Heat delays skin wound healing in mice

2016 ◽  
Vol 242 (3) ◽  
pp. 258-266 ◽  
Author(s):  
Marco Aurélio dos Santos-Silva ◽  
Eduardo Tavares Lima Trajano ◽  
Fernanda Seabra Schanuel ◽  
Andréa Monte-Alto-Costa
Keyword(s):  
Wound Healing ◽  
Protein Expression ◽  
Visible Light ◽  
Type I Collagen ◽  
In Vivo Studies ◽  
Type Iii Collagen ◽  
Type I ◽  
Skin Wound Healing ◽  
Thermal Chamber

In vivo studies have shown that the combination of infrared radiation (IR) and visible light (VIS) is responsible for the activation of metaloproteinases, causing matrix degradation and damage to healthy skin. However, the role of heat originating from the VIS spectrum on wound healing remains poorly understood. Our objective was to investigate the macroscopic, microscopic and biochemical effects of heat induced by visible light on cutaneous wound healing in mice. Male mice were anesthetized, subjected to a cutaneous excisional wound and divided into two groups ( n = 10/group) exposed to 23℃ or 43℃ in a thermal chamber for 30 min every other day, for 13 days. On day 14, the animals were sacrificed, and their lesions were processed for histochemistry, immunohistochemistry and protein expression analysis. The wound area was 42% greater 11 days ( p < 0.01) and 29% greater 14 days ( p < 0.001) after wounding in the 43℃ group than in the 23℃ group. The 43℃ group presented a lower (17%) percentage of reepithelialized wounds ( p < 0.001) 14 days after wounding. The length of the epidermal gap was greater in the 43℃ group ( p < 0.01). The volume density of myofibroblasts and the number of F4/80-positive macrophages was greater in the 43℃ group ( p < 0.05). The 43℃ group showed increased protein expression of type III collagen ( p < 0.001), decreased protein expression of type I collagen ( p < 0.05), increased MMP-1 expression ( p < 0.05), and decreased MMP-2 activity ( p < 0.001). The protein expression of fibrillin-1 ( p < 0.001), MMP-12 ( p < 0.05), TGF-β 1/2/3 ( p < 0.01) and ERK activation ( p < 0.05) was increased in the 43℃ group. Our results suggest that heat delays the stages of wound healing in mice.

scholarly journals Doxorubicin·Hydrochloride/Cisplatin-Loaded Hydrogel/Nanosized (2-Hydroxypropyl)-Beta-Cyclodextrin Local Drug-Delivery System for Osteosarcoma Treatment In Vivo

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1652 ◽  
Author(s):  
Sun Jung Yoon ◽  
Young Jae Moon ◽  
Heung Jae Chun ◽  
Dae Hyeok Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Glycol Chitosan ◽  
Beta Cyclodextrin ◽  
Osa Treatment ◽  
Local Drug Delivery System ◽  
Hydroxypropyl Beta Cyclodextrin

Osteosarcoma (OSA) is a difficult cancer to treat due to its tendency for relapse and metastasis; advanced methods are therefore required for OSA treatment. In this study, we prepared a local drug-delivery system for OSA treatment based on doxorubicin·hydrochloride (DOX·HCl)/cisplatin (CP)-loaded visible light-cured glycol chitosan (GC) hydrogel/(2-hydroxypropyl)-beta-cyclodextrin (GDHCP), and compared its therapeutic efficiency with that of DOX·HCl- and CP-loaded GC hydrogels (GD and GHCP). Because of diffusion driven by concentration gradients in the swollen matrix, the three hydrogels showed sustained releases of DOX·HCl and CP over 7 days, along with initial 3-h bursts. Results of in vitro cell viability and in vivo animal testing revealed that GDHCP had a stronger anticancer effect than GD and GHCP even though there were no significant differences. Body weight measurement and histological evaluations demonstrated that the drug-loaded GC hydrogels had biocompatibility without cardiotoxicity or nephrotoxicity. These results suggested that GDHCP could be a good platform as a local drug-delivery system for clinical use in OSA treatment.

Polyethylene‐glycol chitosan hydrogel accelerates traumatic wound healing in diabetic mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Angel Eduardo Bárcenas García ◽  
Miriam Veronica Flores Merino ◽  
Ibeth Mayerly Gaitan Tolosa ◽  
Daniela Rodríguez Muñoz ◽  
Miguel Angel Camacho López ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyethylene Glycol ◽  
Diabetic Mice ◽  
Glycol Chitosan ◽  
Chitosan Hydrogel ◽  
Traumatic Wound
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