Role of hydrogen bonding studied by the FTIR spectroscopy of the matrix-isolated molecular complexes, dimer of water, water.carbon dioxide, water.carbon monoxide and hydrogen peroxide.n carbon monoxide in solid molecular oxygen at 12-17 K

1985 ◽  
Vol 89 (9) ◽  
pp. 1612-1618 ◽  
Author(s):  
Tai Ly Tso ◽  
Edward K. C. Lee
Keyword(s):  
Carbon Monoxide ◽  
Hydrogen Bonding ◽  
Ftir Spectroscopy ◽  
Molecular Oxygen ◽  
Molecular Complexes ◽  
The Matrix

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

scholarly journals The role of heme oxygenase and carbon monoxide in inflammatory bowel disease

Redox Report ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 193-201 ◽  
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Kazuhiko Uchiyama ◽  
Toshikazu Yoshikawa
Keyword(s):  
Inflammatory Bowel Disease ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Bowel Disease ◽  
Inflammatory Bowel

Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes

2021 ◽  
Vol 95 (4) ◽  
pp. 1141-1159
Author(s):  
Rong-Jane Chen ◽  
Yu-Hsuan Lee ◽  
Tzu-Hao Chen ◽  
Yu-Ying Chen ◽  
Ya-Ling Yeh ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Health Effects

scholarly journals Deciphering the Role of π-Interactions in Polyelectrolyte Complexes Using Rationally Designed Peptides

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2074
Author(s):  
Sara Tabandeh ◽  
Cristina Elisabeth Lemus ◽  
Lorraine Leon
Keyword(s):  
Hydrogen Bonding ◽  
Phase Separation ◽  
Liquid Phase ◽  
Charge Density ◽  
Secondary Structures ◽  
Liquid Phase Separation ◽  
Polyelectrolyte Complexes ◽  
Π Interactions ◽  
Liquid Liquid Phase Separation

Electrostatic interactions, and specifically π-interactions play a significant role in the liquid-liquid phase separation of proteins and formation of membraneless organelles/or biological condensates. Sequence patterning of peptides allows creating protein-like structures and controlling the chemistry and interactions of the mimetic molecules. A library of oppositely charged polypeptides was designed and synthesized to investigate the role of π-interactions on phase separation and secondary structures of polyelectrolyte complexes. Phenylalanine was chosen as the π-containing residue and was used together with lysine or glutamic acid in the design of positively or negatively charged sequences. The effect of charge density and also the substitution of fluorine on the phenylalanine ring, known to disrupt π-interactions, were investigated. Characterization analysis using MALDI-TOF mass spectroscopy, H NMR, and circular dichroism (CD) confirmed the molecular structure and chiral pattern of peptide sequences. Despite an alternating sequence of chirality previously shown to promote liquid-liquid phase separation, complexes appeared as solid precipitates, suggesting strong interactions between the sequence pairs. The secondary structures of sequence pairs showed the formation of hydrogen-bonded structures with a β-sheet signal in FTIR spectroscopy. The presence of fluorine decreased hydrogen bonding due to its inhibitory effect on π-interactions. π-interactions resulted in enhanced stability of complexes against salt, and higher critical salt concentrations for complexes with more π-containing amino acids. Furthermore, UV-vis spectroscopy showed that sequences containing π-interactions and increased charge density encapsulated a small charged molecule with π-bonds with high efficiency. These findings highlight the interplay between ionic, hydrophobic, hydrogen bonding, and π-interactions in polyelectrolyte complex formation and enhance our understanding of phase separation phenomena in protein-like structures.

scholarly journals The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 188
Author(s):  
Małgorzata Makarewicz ◽  
Iwona Drożdż ◽  
Tomasz Tarko ◽  
Aleksandra Duda-Chodak
Keyword(s):  
Intestinal Bacteria ◽  
Research Data ◽  
Bioactive Metabolites ◽  
Human Organism ◽  
Comprehensive Knowledge ◽  
Bidirectional Relationship ◽  
The Matrix ◽  
Intestinal Pathogens ◽  
The Impact

This review presents the comprehensive knowledge about the bidirectional relationship between polyphenols and the gut microbiome. The first part is related to polyphenols’ impacts on various microorganisms, especially bacteria, and their influence on intestinal pathogens. The research data on the mechanisms of polyphenol action were collected together and organized. The impact of various polyphenols groups on intestinal bacteria both on the whole “microbiota” and on particular species, including probiotics, are presented. Moreover, the impact of polyphenols present in food (bound to the matrix) was compared with the purified polyphenols (such as in dietary supplements) as well as polyphenols in the form of derivatives (such as glycosides) with those in the form of aglycones. The second part of the paper discusses in detail the mechanisms (pathways) and the role of bacterial biotransformation of the most important groups of polyphenols, including the production of bioactive metabolites with a significant impact on the human organism (both positive and negative).

scholarly journals What is beyond the edges? Gated communities and their role in China’s desire for harmonious cities

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Badiaa Hamama ◽  
Jian Liu
Keyword(s):  
Economic Growth ◽  
Real Estate ◽  
Urban Form ◽  
Gated Communities ◽  
Urban Fabric ◽  
Chinese Cities ◽  
The Matrix ◽  
Process Of Urbanization ◽  
New Urbanization

Abstract During the rapid process of urbanization in post-reform China, cities assumed the role of a catalyst for economic growth and quantitative construction. In this context, territorially bounded and well delimited urban cells, globally known as ‘gated communities’, xiaoqu, continued to define the very essence of Chinese cities becoming the most attractive urban form for city planners, real estate developers, and citizens alike. Considering the guidelines in China’s National New Urbanization Plan (2014–2020), focusing on the promotion of humanistic and harmonious cities, in addition to the directive of 2016 by China’s Central Urban Work Conference to open up the gates and ban the construction of new enclosed residential compounds, this paper raises the following questions: As the matrix of the Chinese urban fabric, what would be the role of the gated communities in China’s desire for a human-qualitative urbanism? And How to rethink the gated communities to meet the new urban challenges? Seeking alternative perspectives, this paper looks at the gated communities beyond the apparent limits they seem to represent, considering them not simply as the ‘cancer’ of Chinese cities, rather the container of the primary ingredients to reshape the urban fabric dominated by the gate.

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