Transition-state switchings for single potential well ionic dissociations

1991 ◽  
Vol 95 (23) ◽  
pp. 9298-9302 ◽  
Author(s):  
C. Lifshitz ◽  
F. Louage ◽  
V. Aviyente ◽  
K. Song
Author(s):  
Jeremy Moore ◽  
Leopoldo L. Martin ◽  
Kyu Hyun Kim ◽  
Hengky Chandrahalim ◽  
Matt Eichenfield ◽  
...  

2019 ◽  
Vol 99 (4) ◽  
Author(s):  
Julien M. E. Fraïsse ◽  
Jae-Gyun Baak ◽  
Uwe R. Fischer

2014 ◽  
Vol 63 (19) ◽  
pp. 193601
Author(s):  
Zhang Xue-Jun ◽  
Rao Jian ◽  
Deng Yang-Bao ◽  
Jiang Lian-jun ◽  
Tian Ye

1988 ◽  
Vol 131 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Yao Huang Kao ◽  
Jeun Chyuan Huang ◽  
Yih Shun Gou

2015 ◽  
Vol 142 (22) ◽  
pp. 224906 ◽  
Author(s):  
Harri Mökkönen ◽  
Timo Ikonen ◽  
Tapio Ala-Nissila ◽  
Hannes Jónsson

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.


1999 ◽  
Vol 97 (8) ◽  
pp. 967-976 ◽  
Author(s):  
M. Garay Salazar, J. M. Orea Rocha, A.

1987 ◽  
Vol 48 (C2) ◽  
pp. C2-19-C2-26
Author(s):  
X. VIÑAS ◽  
A. GUIRAO

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