Diffusion Model of Solid-State Catalytic Hydrogen Isotope Exchange-Isotopomer Formation Kinetics and Reaction Mechanism

1994 ◽  
Vol 98 (15) ◽  
pp. 3924-3926 ◽  
Author(s):  
Anton V. Filikov ◽  
John R. Jones ◽  
Nikolai F. Myasoedov
Keyword(s):  
Reaction Mechanism ◽  
Solid State ◽  
Diffusion Model ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange ◽  
Formation Kinetics ◽  
Catalytic Hydrogen

scholarly journals Highly active iridium(i) complexes for catalytic hydrogen isotope exchange

2008 ◽  
pp. 1115 ◽  
Author(s):  
Jack A. Brown ◽  
Stephanie Irvine ◽  
Alan R. Kennedy ◽  
William J. Kerr ◽  
Shalini Andersson ◽  
...  
Keyword(s):  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange ◽  
Highly Active ◽  
Catalytic Hydrogen

scholarly journals Solid state catalytic hydrogen exchange for deuterium in cycloprolylglycine

2019 ◽  
Vol 484 (3) ◽  
pp. 307-311
Author(s):  
A. K. Dadayan ◽  
Yu. A. Borisov ◽  
E. V. Bocharov ◽  
Yu. A. Zolotarev ◽  
I. Yu. Nagaev ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Solid State ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Density Functional ◽  
Hydrogen Exchange ◽  
Functional Theory ◽  
Catalytic Hydrogen ◽  
Spillover Hydrogen ◽  
High Stereoselectivity

The reaction of spillover hydrogen (SH) with cyclopropylglycine (cPG) in high-temperature solid-state catalytic hydrogen isotope exchange (HTCIE) has been studied experimentally and using density functional theory (DFT). NMR spectroscopy and mass spectrometry have shown a high regioselectivity and stereoselectivity for the reaction of spillover hydrogen with cPG fragments. The Gly fragment has been shown to be the most reactive in HTCIE, for which high stereoselectivity of substitution of hydrogen by deuterium has been demonstrated.

scholarly journals Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N ‐Heterocycles and Reaction Mechanism Insights

2020 ◽  
Vol 26 (22) ◽  
pp. 4988-4996 ◽  
Author(s):  
Viktor Pfeifer ◽  
Marie Certiat ◽  
Donia Bouzouita ◽  
Alberto Palazzolo ◽  
Sébastien Garcia‐Argote ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Complex Molecules ◽  
Hydrogen Isotope Exchange

scholarly journals Inside Cover: The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange (Adv. Synth. Catal. 17/2014)

2014 ◽  
Vol 356 (17) ◽  
pp. 3474-3474
Author(s):  
Jack A. Brown ◽  
Alison R. Cochrane ◽  
Stephanie Irvine ◽  
William J. Kerr ◽  
Bhaskar Mondal ◽  
...  
Keyword(s):  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange ◽  
Highly Active ◽  
Catalytic Hydrogen

Experimental and ab Initio Studies on Solid-State Hydrogen Isotope Exchange with Spillover Tritium

1999 ◽  
Vol 103 (25) ◽  
pp. 4861-4864 ◽  
Author(s):  
Yurii A. Zolotarev ◽  
Yurii A. Borisov ◽  
Nikolai F. Myasoedov
Keyword(s):  
Solid State ◽  
Ab Initio ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange

Study of the solid-state hydrogen isotope exchange ofl-alanine

1997 ◽  
Vol 46 (4) ◽  
pp. 726-731 ◽  
Author(s):  
Yu. A. Zolotarev ◽  
E. V. Laskatelev ◽  
V. S. Kozik ◽  
E. M. Dorokhova ◽  
S. G. Rozenberg ◽  
...  
Keyword(s):  
Solid State ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange

scholarly journals Development of an analytical diffusion model for modeling hydrogen isotope exchange

2015 ◽  
Vol 463 ◽  
pp. 1129-1133 ◽  
Author(s):  
J.L. Barton ◽  
Y.Q. Wang ◽  
R.P. Doerner ◽  
G.R. Tynan
Keyword(s):  
Diffusion Model ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Hydrogen Isotope Exchange

Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization

Synlett ◽  
2021 ◽  
Author(s):  
Hang Shi ◽  
Qi-Kai Kang
Keyword(s):  
Transition Metal ◽  
Late Stage ◽  
Hydrogen Isotope ◽  
Isotope Exchange ◽  
Exchange Reactions ◽  
Complex Molecules ◽  
Hydrogen Isotope Exchange ◽  
Catalytic Hydrogen ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

AbstractThe introduction of deuterium and tritium into molecules is of great importance in drug discovery. Many attempts have been made to develop late-stage hydrogen isotope exchange (HIE) reactions to avoid multistep syntheses using commercially available labeled precursors. In this review, we summarize recent progress in catalytic HIE reactions, with our main focus on their applications in the late-stage labeling of bioactive complex molecules and pharmaceuticals1 Introduction2 Non-Transition-Metal-Catalyzed Hydrogen Isotope Exchange2.1 Organocatalysis2.2 Photoredox Catalysis3 Transition-Metal-Catalyzed Hydrogen Isotope Exchang3.1 Palladium3.2 Ruthenium3.3 Iridium3.4 Other Metals4 Summary

Sign in / Sign up

Export Citation Format

Share Document