A Novel Method for Molybdenum-99/Technetium-99m Recovery via Anodic Carbonate Dissolution of Irradiated Low-Enriched Uranium Metal Foil

2015 ◽  
Vol 54 (2) ◽  
pp. 712-719 ◽  
Author(s):  
M. Alex Brown ◽  
Artem V. Gelis ◽  
Jeffrey A. Fortner ◽  
James L. Jerden ◽  
Stan Wiedmeyer ◽  
...  
Keyword(s):  
Metal Foil ◽  
Carbonate Dissolution ◽  
Uranium Metal ◽  
Technetium 99M ◽  
Novel Method ◽  
Enriched Uranium

Thermal-Mechanical Response of Non-Uniformly Heated LEU Foil Based Target

2011 ◽  
Author(s):  
Kyler K. Turner ◽  
Gary L. Solbrekken ◽  
Charlie W. Allen
Keyword(s):  
Mechanical Response ◽  
Metal Foil ◽  
Transfer Coefficients ◽  
Technetium 99M ◽  
Heat Transfer Coefficients ◽  
Plate Design ◽  
Enriched Uranium ◽  
Aluminum Plates ◽  
Sandwiched Structure ◽  
Global Threat

Technetium-99m is a diagnostic radiopharmaceutical that is currently used in 80% of the global nuclear diagnostic imaging procedures. The parent isotope for technetium-99m is molybdenum-99, most commonly obtained through the irradiation of high enriched uranium (HEU) targets. In accordance with the Department of Energy’s Global Threat Reduction Initiative (GTRI) an effort is underway to develop a process to produce molybdenum-99 using low enriched uranium (LEU) targets to maintain production yield relative to HEU targets. Conversion of targets to LEU material effectively mandates that the most efficient process is to cast LEU in the form of a metal foil as opposed to current powder based dispersion designs for HEU. Using a foil requires a significant modification to the current target design. One design concept uses an LEU foil sandwiched between two nominally flat aluminum plates. The LEU is enclosed in the sandwiched structure by welding the aluminum plates together about their edges. The plate design is inspired by high density monolithic LEU fuel plates with the exception that the LEU is not bonded to the aluminum plates nor is it necessary to clamp the plate edges to prevent lateral translation. The lack of bonding between the LEU foil and the plates allows the edges of the plate to be cut off so the foil can be removed after irradiation to be chemically processed. The un-heated edges of the plate target produce 3-D temperature gradients that induce plate deformations. This paper will review thermal mechanical response of an LEU foil based molybdenum-99 plate target geometry. This study describes the effect of various edge holding conditions, thermal loads, and heat transfer coefficients on the thermal-induced deflection and stress in the plates.

A novel method for the non-chromatographic purification of technetium-99m-labeled monoclonal antibodies: a study with B72.3 monoclonal antibody

1994 ◽  
Vol 21 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Howard S. Rosenzweig ◽  
Girish N. Ranadive ◽  
Troy Seskey ◽  
Michael W. Epperly ◽  
William D. Bloomer
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Chromatographic Purification ◽  
Technetium 99M ◽  
Novel Method

Thermal-Mechanical Response of Non-Uniformly Heated Nominally Flat and Curved LEU Foil Based Target

2012 ◽  
Author(s):  
Kyler K. Turner ◽  
Gary L. Solbrekken ◽  
Charlie W. Allen
Keyword(s):  
Mechanical Response ◽  
Three Dimensional ◽  
Department Of Energy ◽  
Transfer Coefficients ◽  
Technetium 99M ◽  
Plate Design ◽  
Enriched Uranium ◽  
Aluminum Plates ◽  
Sandwiched Structure ◽  
Global Threat

Technetium-99m is a radiopharmaceutical currently used in 85% of all diagnostic imaging procedures. The relative long lived parent isotope of technetium-99m is molybdenum-99, which is commonly produced by irradiating highly enriched uranium. In accordance with the Department of Energy: National Nuclear Security Administration’s Global Threat Reduction Initiative an effort is underway to develop low enriched uranium based molybdenum-99 production concepts. Achieving comparable molybdenum-99 yields in a low enriched uranium target effectively mandates the use of a high density metal low enriched uranium foil. Using a foil requires a significant modification to the current highly enriched uranium dispersion target designs. One design concept uses a low enriched uranium foil sandwiched between either two flat or curved aluminum plates. The low enriched uranium is enclosed in the sandwiched structure by welding the aluminum plates together about their edges. The plate design is inspired by low enriched uranium fuel plates with the exception that the low enriched uranium is not bonded to the aluminum plates nor is it necessary to clamp the plate edges to prevent lateral translation. The lack of bonding between the low enriched uranium foil and the plates allows easy removal of the foil after irradiation for chemically processing and separation. The un-heated edges of the plate target produce three-dimensional temperature gradients inducing deformations and stress. This paper will review the thermal mechanical response of a low enriched uranium foil based molybdenum-99 production target. This study describes the effect of various curvatures, thermal loads, and heat transfer coefficients on the thermal-induced deflection and stress.

Critical Mass Irregularity of Steel-Moderated Enriched Uranium Metal Assemblies with Composite Steel-Oil Reflectors

1970 ◽  
Vol 39 (3) ◽  
pp. 320-328 ◽  
Author(s):  
Donald C. Coonfield ◽  
Grover Tuck ◽  
Harold E. Clark ◽  
Bruce B. Ernst
Keyword(s):  
Critical Mass ◽  
Uranium Metal ◽  
Enriched Uranium ◽  
Composite Steel

Reactor Physics Parameters of 1.03% Enriched Uranium Metal, D2O Moderated Lattices

1968 ◽  
Vol 32 (3) ◽  
pp. 283-291 ◽  
Author(s):  
Walter H. D’Ardenne ◽  
Henry E. Bliss ◽  
David D. Lanning ◽  
Irving Kaplan ◽  
Theos J. Thompson
Keyword(s):  
Reactor Physics ◽  
Uranium Metal ◽  
Enriched Uranium
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