Transition State and G2Q Analysis of Hydrocarbon Radical Reactions with Cl2

1995 ◽  
Vol 34 (12) ◽  
pp. 4202-4211 ◽  
Author(s):  
Max Markus Tirtowidjojo ◽  
Brenda Thies Colegrove ◽  
Joseph L. Durant
Keyword(s):  
Transition State ◽  
Radical Reactions ◽  
Hydrocarbon Radical

Ab Initio Calculations for Hydrocarbons:  Enthalpy of Formation, Transition State Geometry, and Activation Energy for Radical Reactions

2003 ◽  
Vol 107 (43) ◽  
pp. 9147-9159 ◽  
Author(s):  
Mark Saeys ◽  
Marie-Françoise Reyniers ◽  
Guy B. Marin ◽  
Veronique Van Speybroeck ◽  
Michel Waroquier
Keyword(s):  
Activation Energy ◽  
Transition State ◽  
Ab Initio Calculations ◽  
Ab Initio ◽  
Enthalpy Of Formation ◽  
Radical Reactions ◽  
Transition State Geometry

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

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