Conjugated Polyrotaxanes Incorporating Mono- or Divalent Copper Complexes

1999 ◽  
Vol 38 (19) ◽  
pp. 4203-4210 ◽  
Author(s):  
Pierre-Louis Vidal ◽  
Bernadette Divisia-Blohorn ◽  
Gérard Bidan ◽  
Jean-Marc Kern ◽  
Jean-Pierre Sauvage ◽  
...  
Keyword(s):  
Copper Complexes ◽  
Divalent Copper

Divalent copper complexes as influenza A M2 inhibitors

2017 ◽  
Vol 147 ◽  
pp. 100-106 ◽  
Author(s):  
Nathan A. Gordon ◽  
Kelly L. McGuire ◽  
Spencer K. Wallentine ◽  
Gregory A. Mohl ◽  
Jonathan D. Lynch ◽  
...  
Keyword(s):  
Influenza A ◽  
Copper Complexes ◽  
Divalent Copper

Effect of ammonia addition to alkaline copper quaternary wood preservative solution on the distribution of copper complexes and leaching

Holzforschung ◽  
2012 ◽  
Vol 66 (3) ◽  
Author(s):  
Sedric Pankras ◽  
Paul A. Cooper
Keyword(s):  
Copper Complexes ◽  
Treated Wood ◽  
Wood Preservative ◽  
Exchange Capacity ◽  
Lower Amount ◽  
Divalent Copper ◽  
Copper Leaching ◽  
Ammonia Addition ◽  
Alkaline Copper Quaternary ◽  
High Ligand

Abstract The effects of ammonia (NH3) addition to monoethanolamine (Mea)-based alkaline copper quaternary (ACQ) on the predicted distribution of cupric (Cu2+) species in solution and copper leaching from treated wood were investigated. Addition of ammonia in higher proportions reduced the amount of neutral copper-Mea complex at high pH and increased the amounts of divalent copper-NH3 complexes. At lower pH, the amounts of high-ligand copper-Mea complexes were reduced. These effects should promote better fixation and diminish copper leaching. However, ammonia addition also reduced the monovalent copper-Mea complex and the amount of copper fixed by precipitation at lower pH. This effect could, potentially, reduce fixation and leach resistance. Ammonia addition to the ACQ formulation from a Cu:Mea:NH3 ratio of 1:4:0 (normal Mea formulation, pH=9) to 1:4:2 (pH 10–10.2) and 1:4:4 (pH 10.4–10.5) did not significantly affect the amount of copper leached. However, a further increase in ammonia to 1:4:6 (pH 10.6–10.7) resulted in a significant reduction in copper leaching. At pH 9, an increase in the proportional amount of ammonia increased the amount of copper leached by reducing the amount of monovalent copper-Mea complex and increasing the divalent copper-NH3 complexes. Ammonia addition with a lower amount of Mea, 1:2.5:4 formulation (pH 10.5–10.7), significantly reduced copper leaching as a result of higher amounts of divalent copper-NH3 complexes adsorbed at higher pH (higher cation exchange capacity) without compromising the amount of copper precipitated at lower pH.

scholarly journals Divalent Copper Complexes as Influenza a M2 S31N Blockers

2016 ◽  
Vol 110 (3) ◽  
pp. 445a
Author(s):  
Kelly L. McGuire ◽  
Spencer Wallentine ◽  
Nathan A. Gordon ◽  
Greg Mohl ◽  
Mckay D. Jensen ◽  
...  
Keyword(s):  
Influenza A ◽  
Copper Complexes ◽  
Divalent Copper

Steric hindrance influence of a diazo link upon mesogenic properties of some ligands and related copper complexes

1997 ◽  
Vol 94 ◽  
pp. 1695-1714 ◽  
Author(s):  
P Lesot ◽  
F Perez ◽  
P Judeinstein ◽  
JP Bayle ◽  
H Allouchi ◽  
...  
Keyword(s):  
Steric Hindrance ◽  
Copper Complexes

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

2019 ◽  
Vol 70 (10) ◽  
pp. 3603-3610
Author(s):  
Madalina Mihalache ◽  
Cornelia Guran ◽  
Aurelia Meghea ◽  
Vasile Bercu ◽  
Ludmila Motelica ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Copper Complexes ◽  
Substrate Adhesion ◽  
Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

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