Anti-Inflammatory Dinuclear Copper(II) Complexes with Indomethacin. Synthesis, Magnetism and EPR Spectroscopy. Crystal Structure of theN,N-Dimethylformamide Adduct

1999 ◽  
Vol 38 (8) ◽  
pp. 1736-1744 ◽  
Author(s):  
Jane E. Weder ◽  
Trevor W. Hambley ◽  
Brendan J. Kennedy ◽  
Peter A. Lay ◽  
Dugald MacLachlan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Epr Spectroscopy ◽  
Dinuclear Copper ◽  
Anti Inflammatory

Oxidation of copper(II) hydroxyporphyrin (oxophlorin); oxidative ring opening and formation of an ester-linked, dinuclear copper complex

2001 ◽  
Vol 79 (5-6) ◽  
pp. 922-929 ◽  
Author(s):  
Shane Phillips ◽  
Bruce C Noll ◽  
Marilyn M Olmstead ◽  
Alan L Balch
Keyword(s):  
Crystal Structure ◽  
Copper Complex ◽  
Epr Spectroscopy ◽  
Ring Opening ◽  
Oxidative Cleavage ◽  
Dinuclear Complex ◽  
Dinuclear Copper ◽  
Ring Opening Reaction ◽  
Copper Porphyrin ◽  
Ester Linkage

Addition of copper(II) acetate to octaethyl(meso-hydroxy)porphyrin (H2OEPOH) in THF under a dinitrogen atmosphere produces CuII(OEPOH), which has been isolated as red crystals and shown to have a meso-hydroxyporphyrin structure by UV-vis and EPR spectroscopy. CuII(OEPOH) undergoes oxidation by dioxygen to form a novel dinuclear copper complex {CuII(OEPOC(O)OEB)CuII}. This dinuclear complex is composed of a copper(II) meso-substituted porphyrin portion (with a planar CuN4 unit), which is attached through an ester linkage to a helical copper(II) tetrapyrrole that has been ring-opened through oxidative cleavage of a second molecule of CuII(OEPOH). The oxidative ring-opening reaction resembles that of natural heme catabolism but is arrested at a stage where the oxidized meso-carbon is still appended to the helical open tetrapyrrole. A mechanism is suggested for this process.Key words: copper porphyrin, crystal structure, porphyrin oxidation, linear tetrapyrrole, hydroxy-porphyrin, oxophlorin.

scholarly journals Crystal structure and anti-inflammatory activity of (3E,5E)-1-((4-chlorophenyl)sulfonyl)-3-(pyridin-4-ylmethylene)-5-(2-(trifluoromethyl)benzylidene)piperidin-4-one, C25H18ClF3N2O3S

2020 ◽  
Vol 235 (2) ◽  
pp. 411-413
Author(s):  
Yan-Qiu Zhou ◽  
Gui-Ge Hou ◽  
Qing-Guo Meng ◽  
Yun Hou
Keyword(s):  
Crystal Structure ◽  
Inflammatory Activity ◽  
Anti Inflammatory

AbstractC25H18ClF3N2O3S, monoclinic, P21/n (no. 14), a = 9.9087(5) Å, b = 21.7843(10) Å, c = 10.2512(6) Å, β = 94.749(5)°, V = 2205.2(2) Å3, Z = 4, Rgt(F) = 0.0448, wRref(F2) = 0.1028, T = 100 K.

Oximato bridged dinuclear copper(II) complexes: Synthesis, crystal structure, magnetic, thermal, electrochemical aspects and BVS analysis

Polyhedron ◽  
2012 ◽  
Vol 43 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Jnan Prakash Naskar ◽  
Bhargab Guhathakurta ◽  
Liping Lu ◽  
Miaoli Zhu
Keyword(s):  
Crystal Structure ◽  
Dinuclear Copper

scholarly journals Crystal structure of bis(μ2-4-tert-butyl-2-formylphenolato)-1:2κ3O1,O2:O1;3:4κ3O1,O2:O1-bis(4-tert-butyl-2-formylphenolato)-2κ2O1,O2;4κ2O1,O2-di-μ3-methoxido-1:2:3κ3O;1:3:4κ3O-di-μ2-methoxido-1:4κ2O;2:3κ2O-tetracopper(II)

2015 ◽  
Vol 71 (3) ◽  
pp. 324-326
Author(s):  
Bernhard Eberhard Christian Bugenhagen ◽  
Marc Heinrich Prosenc
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonding ◽  
Coordination Sphere ◽  
Title Compound ◽  
Coordination Environment ◽  
Dinuclear Copper ◽  
Tert Butyl ◽  
Hydrogen Bonding Interactions ◽  
Square Planar

The structure of the title compound, [Cu4(CH3O)4(C11H13O2)4], consists of dimeric dinuclear copper(II) complexes oriented around a centre of inversion. Within each dinuclear fragment, the two CuIIatoms are in a distorted square-planar coordination sphere. Two neighbouring fragments are linked by four apical Cu—O contacts, yielding an overall square-pyramidal coordination environment for each of the four CuIIatoms. The molecules are arranged in layers parallel to (101). Non-classical C—H...O hydrogen-bonding interactions are observed between the layers.

Synthesis, Crystal Structure and Luminescent Properties of A Dinuclear Copper(I) Complex Containing 2,9-di-n-butyl-1,10-phenanthroline

2012 ◽  
Vol 33 (12) ◽  
pp. 1277-1282
Author(s):  
刘文崧 LIU Wen-song ◽  
任泓扬 REN Hong-yang ◽  
李湘祁 LI Xiang-qi ◽  
王炳喜 WANG Bing-xi
Keyword(s):  
Crystal Structure ◽  
Luminescent Properties ◽  
Dinuclear Copper
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