The Metal Loading Ability of β-Amyloid N-Terminus: A Combined Potentiometric and Spectroscopic Study of Copper(II) Complexes with β-Amyloid(1−16), Its Short or Mutated Peptide Fragments, and Its Polyethylene Glycol (PEG)-ylated Analogue

2008 ◽  
Vol 47 (20) ◽  
pp. 9669-9683 ◽  
Author(s):  
Chiara A. Damante ◽  
Katalin Ösz ◽  
Zoltán Nagy ◽  
Giuseppe Pappalardo ◽  
Giulia Grasso ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Spectroscopic Study ◽  
Peptide Fragments ◽  
Metal Loading ◽  
N Terminus ◽  
Β Amyloid

scholarly journals Copper(II) Coordination Abilities of the Tau Protein's N‐Terminus Peptide Fragments: A Combined Potentiometric, Spectroscopic and Mass Spectrometric Study

ChemPlusChem ◽  
2019 ◽  
Vol 84 (11) ◽  
pp. 1697-1708 ◽  
Author(s):  
Márton Lukács ◽  
Györgyi Szunyog ◽  
Ágnes Grenács ◽  
Norbert Lihi ◽  
Csilla Kállay ◽  
...  
Keyword(s):  
Mass Spectrometric Study ◽  
Mass Spectrometric ◽  
Spectrometric Study ◽  
Peptide Fragments ◽  
N Terminus

In vitrometabolism of an insect neuropeptide by homogenates of the nematodeCaenorhabditis elegans

2003 ◽  
Vol 77 (1) ◽  
pp. 43-48 ◽  
Author(s):  
E.P. Masler
Keyword(s):  
General Pattern ◽  
Residue Analysis ◽  
Aminopeptidase Activity ◽  
Soil Nematode ◽  
Peptide Fragments ◽  
Adipokinetic Hormone ◽  
Initial Product ◽  
Insect Neuropeptide ◽  
Endoproteolytic Cleavage ◽  
N Terminus

AbstractThe cytosolic fraction of homogenates from the free-living soil nematodeCaenorhabditis elegansis capable of metabolizing the insect neuropeptide adipokinetic hormone, a decapeptide blocked at the N-terminus by a pGlu residue. Analysis of digests by RP-HPLC and LC-MS revealed that an initial endoproteolytic cleavage step produced a heptapeptide with an unblocked N-terminus that can serve as a substrate for aminopeptidases. The aminopeptidase activity is depressed in the presence of the inhibitor amastatin; the initial product of the endoproteolytic step accumulates during incubation, and expected aminopeptidase product peptides are reduced in amount, as assessed by chromatographic peak size. The absence of some expected peptide fragments in the reaction mixtures suggests that multiple proteases contribute to short peptide half-lives. Comparison of the adipokinetic hormone digestion inC. elegansto that reported previously for insects reveals the same general pattern of peptide fragment production.

P4-329: Different susceptibilities of oligomeric and fibrillar forms of β-amyloid to antibodies specific to N-terminus of this peptide

2006 ◽  
Vol 2 ◽  
pp. S613-S614 ◽  
Author(s):  
Michael Agadjanyan ◽  
Grigor Mamikonyan ◽  
Mihaela Necula ◽  
Mikayel Mkrtichyan ◽  
Anahit Ghochikyan ◽  
...  
Keyword(s):  
N Terminus ◽  
Β Amyloid

A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein

2006 ◽  
Vol 40 (7) ◽  
pp. 731-739 ◽  
Author(s):  
Brian J. Tabner ◽  
Stuart Turnbull ◽  
Jenny E. King ◽  
Fiona E. Benson ◽  
Omar M.A. El-Agnaf ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Spectroscopic Study ◽  
Β Amyloid ◽  
Radical Attack

scholarly journals Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease

2017 ◽  
Vol 25 (1) ◽  
pp. 153-164 ◽  
Author(s):  
Irina Petrushina ◽  
Hayk Davtyan ◽  
Armine Hovakimyan ◽  
Arpine Davtyan ◽  
Giselle F. Passos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Therapeutic Vaccines ◽  
Model Of Alzheimer’S Disease ◽  
N Terminus ◽  
Β Amyloid
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