Substitution reactions of metallic complexes of .beta.,.beta.',.beta.''-triaminotriethylamine. 13. Kinetics of solvolysis of the dichloro(.beta.,.beta.',.beta.''-triaminotriethylamine)cobalt(III) and -chromium(III) cations in nonaqueous media and synthesis and characterization of some cobalt(III) and chromium(III) halo-tren complexes containing coordinated neutral nonaqueous ligands

1981 ◽  
Vol 20 (3) ◽  
pp. 723-727 ◽  
Author(s):  
Michael J. Saliby ◽  
David. West ◽  
Stanley K. Madan
1994 ◽  
Vol 67 (9) ◽  
pp. 2590-2592 ◽  
Author(s):  
Shuichi Ikenoue ◽  
Masahiro Mikuriya ◽  
Osamu Miyauchi ◽  
Ryoji Nukada ◽  
Atsushi Yagasaki

Biopolymer has full application as a drug carrier and scaffold in tissue engineering because of its biodegradability and non-toxicity. The present study is focused on novel biopolymer gellan gum as a drug delivery agent. The objective of the study is to synthesize the gellan gum nanoparticle by solvent evaporation emulsification method and characterize it using SEM, DLS, FTIR, and XRD. As pyridoxine is effectively used to treat diabetic peripheral neuropathy, it has been encapsulated with gellan gum and characterized. The antioxidant assay was performed using ABTS reagent, and the activity increases with increasing concentration of nanoparticle. Also, it has significant antimicrobial activity against gram-positive bacteria. Apart from this, the drug release kinetics of the gellan gum- pyridoxine nanoparticle was studied.


2021 ◽  
Author(s):  
Lamia Bennabi ◽  
Ilham Abedelemalek ◽  
Abedelkader Ammari ◽  
Khaldia Sediri ◽  
Fatima Bennabi ◽  
...  

Abstract We presents in this work the preparation of several formulations, based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) loaded with Erythromycin (ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via simple evaporation method by simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried-out by Agar diffusion disc method. The results show that PCL/PLGA blend and PCL alone inhibited the strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.


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