Synthesis of metal complexes with macrocyclic ligands having prescribed patterns of unsaturation. Oxidative dehydrogenation of fused-ring systems involving charged, delocalized six-membered chelate rings

1972 ◽  
Vol 11 (9) ◽  
pp. 1988-1994 ◽  
Author(s):  
Christian J. Hipp ◽  
Leonard F. Lindoy ◽  
Daryle H. Busch
Keyword(s):  
Metal Complexes ◽  
Oxidative Dehydrogenation ◽  
Macrocyclic Ligands ◽  
Ring Systems ◽  
Fused Ring ◽  
Chelate Rings

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

Binuclear and polynuclear transition metal complexes with macrocyclic ligands 7. Directed step-by-step synthesis of novel unsymmetric macrocyclic ligands

2005 ◽  
Vol 54 (9) ◽  
pp. 2219-2223 ◽  
Author(s):  
V. V. Roznyatovsky ◽  
N. E. Borisova ◽  
M. D. Reshetova ◽  
A. G. Buyanovskaya ◽  
Yu. A. Ustynyuk
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Macrocyclic Ligands
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