Water-Soluble Tb3+ and Eu3+ Complexes with Ionophilic (Ionically Tagged) Ligands as Fluorescence Imaging Probes

2013 ◽  
Vol 52 (17) ◽  
pp. 10199-10205 ◽  
Author(s):  
Julia R. Diniz ◽  
José R. Correa ◽  
Daniel de A. Moreira ◽  
Rafaela S. Fontenele ◽  
Aline L. de Oliveira ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Water Soluble ◽  
Imaging Probes

scholarly journals Near Infrared Fluorescence Imaging of Intraperitoneal Ovarian Tumors in Mice Using Erythrocyte-Derived Optical Nanoparticles and Spatially-Modulated Illumination

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2544
Author(s):  
Joshua M. Burns ◽  
Elise Shafer ◽  
Raviraj Vankayala ◽  
Vikas Kundra ◽  
Bahman Anvari
Keyword(s):  
Fluorescence Imaging ◽  
Cytoreductive Surgery ◽  
Animal Studies ◽  
Near Infrared ◽  
Gynecological Cancer ◽  
Ovarian Tumors ◽  
Structured Illumination ◽  
Spatial Frequencies ◽  
Imaging Probes ◽  
Intraoperative Fluorescence Imaging

Ovarian cancer is the deadliest gynecological cancer. Cytoreductive surgery to remove primary and intraperitoneal tumor deposits remains as the standard therapeutic approach. However, lack of an intraoperative image-guided approach to enable the visualization of all tumors can result in incomplete cytoreduction and recurrence. We engineered nano-sized particles derived from erythrocytes that encapsulate the near infrared (NIR) fluorochrome, indocyanine green, as potential imaging probes for tumor visualization during cytoreductive surgery. Herein, we present the first demonstration of the use of these nanoparticles in conjunction with spatially-modulated illumination (SMI), at spatial frequencies in the range of 0–0.5 mm−1, to fluorescently image intraperitoneal ovarian tumors in mice. Results of our animal studies suggest that the nanoparticles accumulated at higher levels within tumors 24 h post-intraperitoneal injection as compared to various other organs. We demonstrate that, under the imaging specifications reported here, use of these nanoparticles in conjunction with SMI enhances the fluorescence image contrast between intraperitoneal tumors and liver, and between intraperitoneal tumors and spleen by nearly 2.1, and 3.0 times, respectively, at the spatial frequency of 0.2 mm−1 as compared to the contrast values at spatially-uniform (non-modulated) illumination. These results suggest that the combination of erythrocyte-derived NIR nanoparticles and structured illumination provides a promising approach for intraoperative fluorescence imaging of ovarian tumor nodules at enhanced contrast.

scholarly journals Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes

2012 ◽  
Vol 23 (4) ◽  
pp. 770-781 ◽  
Author(s):  
Brenno A. D. Neto ◽  
José R. Corrêa ◽  
Pedro H. P. R. Carvalho ◽  
Diego C. B. D. Santos ◽  
Bruna C. Guido ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Live Cell ◽  
Imaging Probes ◽  
Mitochondrial Staining

Ln3+-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice

Nanoscale ◽  
2020 ◽  
Vol 12 (15) ◽  
pp. 8248-8254 ◽  
Author(s):  
Cong Cao ◽  
Na Wu ◽  
Wei Yuan ◽  
Yuyang Gu ◽  
Jiaming Ke ◽  
...  
Keyword(s):  
High Resolution ◽  
Blood Vessels ◽  
Fluorescence Imaging ◽  
Water Soluble

The water-soluble PEG-Er,Ce-CSS probe exhibits largely enhanced NIR-II fluorescence for continuous high-resolution fluorescence imaging.

A water-soluble and upconverting Sr2LaF7: Yb/Er@PSIoAm bio-probe for in vitro/vivo fluorescence imaging

2020 ◽  
pp. 110652
Author(s):  
Yinsheng Tan ◽  
Hua Wang ◽  
Lijun Xiang ◽  
Hongping Zhou ◽  
Lin Kong ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Water Soluble

Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging

2020 ◽  
Vol 49 (22) ◽  
pp. 7294-7298 ◽  
Author(s):  
Thines Kanagasundaram ◽  
Carsten S. Kramer ◽  
Eszter Boros ◽  
Klaus Kopka
Keyword(s):  
Optical Imaging ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Near Infrared Fluorescence ◽  
Technetium 99M ◽  
Imaging Probes ◽  
Near Infrared Fluorescence Imaging

The first technetium-99m tricarbonyl core labelled fluorescent Si-rhodamine and its rhenium analogue for bimodal SPECT- and near-infrared fluorescence imaging is presented.

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