Water-Soluble Donor–Acceptor–Donor-Based Fluorophore for High-Resolution NIR-II Fluorescence Imaging Applications

2021 ◽  
Author(s):  
Kun He ◽  
Shangyu Chen ◽  
Yan Chen ◽  
Jiewei Li ◽  
Pengfei Sun ◽  
...  
Keyword(s):  
High Resolution ◽  
Fluorescence Imaging ◽  
Water Soluble ◽  
Donor Acceptor

Ln3+-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice

Nanoscale ◽  
2020 ◽  
Vol 12 (15) ◽  
pp. 8248-8254 ◽  
Author(s):  
Cong Cao ◽  
Na Wu ◽  
Wei Yuan ◽  
Yuyang Gu ◽  
Jiaming Ke ◽  
...  
Keyword(s):  
High Resolution ◽  
Blood Vessels ◽  
Fluorescence Imaging ◽  
Water Soluble

The water-soluble PEG-Er,Ce-CSS probe exhibits largely enhanced NIR-II fluorescence for continuous high-resolution fluorescence imaging.

scholarly journals Hawk-Seq™ differentiates between various mutations in Salmonella typhimurium TA100 strain caused by exposure to Ames test-positive mutagens

Mutagenesis ◽  
2021 ◽  
Author(s):  
Yuki Otsubo ◽  
Shoji Matsumura ◽  
Naohiro Ikeda ◽  
Osamu Morita
Keyword(s):  
High Resolution ◽  
Salmonella Typhimurium ◽  
Nitro Compound ◽  
Aromatic Amines ◽  
Ames Test ◽  
Alkylating Agents ◽  
Water Soluble ◽  
Base Substitution ◽  
Aromatic Nitro Compound ◽  
Aromatic Nitro

Abstract A precise understanding of differences in genomic mutations according to the mutagenic mechanisms detected in mutagenicity data is required to evaluate the carcinogenicity of environmental mutagens. Recently, we developed a highly accurate genome sequencing method, ‘Hawk-Seq™’, that enables the detection of mutagen-induced genome-wide mutations. However, its applicability to detect various mutagens and identify differences in mutational profiles is not well understood. Thus, we evaluated DNA samples from Salmonella typhimurium TA100 exposed to 11 mutagens including alkylating agents, aldehydes, an aromatic nitro compound, epoxides, aromatic amines, and polycyclic aromatic hydrocarbons (PAHs). We extensively analysed mutagen-induced mutational profiles and their association with the mechanisms of mutagens. Hawk-Seq™ sensitively detected mutations induced by all 11 mutagens, including one that increased the number of revertants by approximately two-fold in the Ames test. Although the sensitivity for less water-soluble mutagens was relatively low, we increased the sensitivity to obtain high-resolution spectra by modifying the exposure protocol. Moreover, two epoxides indicated similar 6-dimensional or 96-dimensional mutational patterns; likewise, three SN1 type alkylating agents indicated similar mutational patterns, suggesting that the mutational patterns are compound category-specific. Meanwhile, an SN2 type alkylating agent exhibited unique mutational patterns compared to those of the SN1 type alkylating agents. Although the mutational patterns induced by aldehydes, the aromatic nitro compound, aromatic amines, and PAHs did not differ substantially from each other, the maximum total base substitution frequencies (MTSFs) were similar among mutagens in the same structural groups. Furthermore, the MTSF was found to be associated with the carcinogenic potency of some direct-acting mutagens. These results indicate that our method can generate high-resolution mutational profiles to identify characteristic features of each mutagen. The detailed mutational data obtained by Hawk-Seq™ can provide useful information regarding mutagenic mechanisms and help identify its association with the carcinogenicity of mutagens without requiring carcinogenicity data.

A Water Soluble Donor-Acceptor [2]Catenane that Can Switch between a Coplanar and a Gemini-Sign Conformation

2010 ◽  
Vol 49 (31) ◽  
pp. 5331-5334 ◽  
Author(s):  
Ho Yu Au-Yeung ◽  
G. Dan Pantoş ◽  
Jeremy K. M. Sanders
Keyword(s):  
Water Soluble ◽  
Donor Acceptor

scholarly journals Multidimensional Analytical Characterization of Water-Soluble Organic Aerosols: Challenges and New Perspectives

2021 ◽  
Vol 11 (6) ◽  
pp. 2539
Author(s):  
Regina M. B. O. Duarte ◽  
João T. V. Matos ◽  
Armando C. Duarte
Keyword(s):  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Organic Aerosols ◽  
Analytical Techniques ◽  
Water Soluble ◽  
Chemical Complexity ◽  
Molecular Features ◽  
High Resolution Mass ◽  
Analytical Strategies ◽  
Resolution Mass

Water-soluble organic aerosols (OA) are an important component of air particles and one of the key drivers that impact both climate and human health. Understanding the processes involving water-soluble OA depends on how well the chemical composition of this aerosol component is decoded. Yet, obtaining detailed information faces several challenges, including water-soluble OA collection, extraction, and chemical complexity. This review highlights the multidimensional non-targeted analytical strategies that have been developed and employed for providing new insights into the structural and molecular features of water-soluble organic components present in air particles. First, the most prominent high-resolution mass spectrometric methods for near real-time measurements of water-soluble OA and their limitations are discussed. Afterward, a special emphasis is given to the degree of compositional information provided by offline multidimensional analytical techniques, namely excitation–emission (EEM) fluorescence spectroscopy, high-resolution mass spectrometry and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and their hyphenation with chromatographic systems. The major challenges ahead on the application of these multidimensional analytical strategies for OA research are also addressed so that they can be used advantageously in future studies.

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