Copper(II) Complexes with Substituted Thiosemicarbazones of α-Ketoglutaric Acid:  Synthesis, X-ray Structures, DNA Binding Studies, and Nuclease and Biological Activity

2004 ◽  
Vol 43 (22) ◽  
pp. 7170-7179 ◽  
Author(s):  
Monica Baldini ◽  
Marisa Belicchi-Ferrari ◽  
Franco Bisceglie ◽  
Pier Paolo Dall'Aglio ◽  
Giorgio Pelosi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Dna Binding ◽  
Acid Synthesis ◽  
Binding Studies ◽  
X Ray ◽  
Dna Binding Studies

The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA

1998 ◽  
Vol 51 (11) ◽  
pp. 977 ◽  
Author(s):  
Chih-Lynne Teo ◽  
Ronald R. Fenton ◽  
Peter Turner ◽  
Trevor W. Hambley
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Molecular Mechanics ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Triclinic Space Group ◽  
X Ray ◽  
Dna Binding Studies ◽  
Total Dna ◽  
R Value

The preparation of [Pt(tmdz)Cl2] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0·048 (764F). The crystals are triclinic, space group P -1, a 8·023(2), b 10·874(4), c 14·207(3) Å, α 95·34(3), β 94·96(2), γ 94·97(3)°. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex—that observed in the crystal structure—is energetically accessible. In total DNA binding studies, [Pt(tmdz)Cl2] binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis.

scholarly journals Synthesis, Characterization and DNA Binding Studies of N,N′-bis(2-Hydroxy-5-methylbenzylidene)- 2-hydroxy-propane-1,3-diamine Copper(II) and Nickel(II) Complexes

2020 ◽  
Vol 32 (7) ◽  
pp. 1667-1675
Author(s):  
Ramina ◽  
Rajkumar Bhubon Singh ◽  
Oinam U-wang ◽  
Thoudam Surchandra Singh ◽  
T. Tiakaba Jamir
Keyword(s):  
Dna Binding ◽  
Transition Metal Complexes ◽  
Planar Geometry ◽  
Spectroscopic Techniques ◽  
Binding Studies ◽  
X Ray ◽  
Intercalative Mode ◽  
Physico Chemical ◽  
Square Planar ◽  
Dna Binding Studies

Two new Schiff base transition metal complexes [Cu(HL)]2.CH3CH2OH (1) and [Ni(HL)] (2) (L = N,N′-bis(2-hydroxy-5-methyl-benzylidene)-2-hydroxy-propane-1,3-diamine) were synthesized and characterized by different physico-chemical and spectroscopic techniques. Structure of complex 1 was determined by single crystal X-ray diffractometer. Both the complexes have distorted square planar geometry. The DNA binding study of two complexes was performed via electronic absorption, cyclic voltammetry, photoluminescence, and viscosity methods and found to be intercalative mode of binding.

Biological activity and DNA binding studies of 2-substituted benzimidazo[1,2-a]quinolines bearing different amino side chains

MedChemComm ◽  
2013 ◽  
Vol 4 (12) ◽  
pp. 1537 ◽  
Author(s):  
Nataša Perin ◽  
Irena Martin-Kleiner ◽  
Raja Nhili ◽  
William Laine ◽  
Marie-Hélène David-Cordonnier ◽  
...  
Keyword(s):  
Biological Activity ◽  
Dna Binding ◽  
Side Chains ◽  
Binding Studies ◽  
Dna Binding Studies
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