DNA binding studies and antibacterial properties of a new Schiff base ligand containing homopiperazine and products of its reaction with Zn(II), Cu(II) and Co(II) metal ions: X-ray crystal structure of Cu(II) and Zn(II) complexes

Polyhedron ◽  
2019 ◽  
Vol 170 ◽  
pp. 584-592 ◽  
Author(s):  
Hassan Keypour ◽  
Fatemeh Forouzandeh ◽  
Sadegh Salehzadeh ◽  
Farshid Hajibabaei ◽  
Saeed Feizi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Dna Binding ◽  
Metal Ions ◽  
Schiff Base Ligand ◽  
Antibacterial Properties ◽  
Binding Studies ◽  
X Ray ◽  
Dna Binding Studies

The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA

1998 ◽  
Vol 51 (11) ◽  
pp. 977 ◽  
Author(s):  
Chih-Lynne Teo ◽  
Ronald R. Fenton ◽  
Peter Turner ◽  
Trevor W. Hambley
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Molecular Mechanics ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Triclinic Space Group ◽  
X Ray ◽  
Dna Binding Studies ◽  
Total Dna ◽  
R Value

The preparation of [Pt(tmdz)Cl2] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0·048 (764F). The crystals are triclinic, space group P -1, a 8·023(2), b 10·874(4), c 14·207(3) Å, α 95·34(3), β 94·96(2), γ 94·97(3)°. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex—that observed in the crystal structure—is energetically accessible. In total DNA binding studies, [Pt(tmdz)Cl2] binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis.

New dinuclear Schiff base complexes of iron(II/III) and copper(II) ions: synthesis, crystal structure, and DNA-binding studies

2019 ◽  
Vol 49 (11) ◽  
pp. 363-374 ◽  
Author(s):  
O. U-Wang ◽  
Rajkumar Bhubon Singh ◽  
Wahengbam Bembee Devi ◽  
Usham Ibotomba Singh ◽  
Rajkumari Bindiya Devi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Binding Studies ◽  
Dna Binding Studies
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