Synthetic analog approach to metallobleomycins: possibility of coordination of the carboxamide group of the .beta.-aminoalaninamide moiety of bleomycin to copper in copper(II) bleomycin at physiological pH

1991 ◽  
Vol 30 (7) ◽  
pp. 1677-1680 ◽  
Author(s):  
Larry A. Scheich ◽  
Patricia. Gosling ◽  
Steven J. Brown ◽  
Marilyn M. Olmstead ◽  
Pradip K. Mascharak
1988 ◽  
Vol 27 (9) ◽  
pp. 1581-1587 ◽  
Author(s):  
Steven J. Brown ◽  
Xiaolin Tao ◽  
Teresa A. Wark ◽  
Douglas W. Stephan ◽  
Pradip K. Mascharak

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Balachandran ◽  
FH Sarkar ◽  
DS Pasco

2020 ◽  
Vol 18 (10) ◽  
pp. 758-768 ◽  
Author(s):  
Khadga Raj ◽  
Pooja Chawla ◽  
Shamsher Singh

: Tramadol is a synthetic analog of codeine used to treat pain of moderate to severe intensity and is reported to have neurotoxic potential. At therapeutic dose, tramadol does not cause major side effects in comparison to other opioid analgesics, and is useful for the management of neurological problems like anxiety and depression. Long term utilization of tramadol is associated with various neurological disorders like seizures, serotonin syndrome, Alzheimer’s disease and Parkinson’s disease. Tramadol produces seizures through inhibition of nitric oxide, serotonin reuptake and inhibitory effects on GABA receptors. Extensive tramadol intake alters redox balance through elevating lipid peroxidation and free radical leading to neurotoxicity and produces neurobehavioral deficits. During Alzheimer’s disease progression, low level of intracellular signalling molecules like cGMP, cAMP, PKC and PKA affect both learning and memory. Pharmacologically tramadol produces actions similar to Selective Serotonin Reuptake Inhibitors (SSRIs), increasing the concentration of serotonin, which causes serotonin syndrome. In addition, tramadol also inhibits GABAA receptors in the CNS has been evidenced to interfere with dopamine synthesis and release, responsible for motor symptoms. The reduced level of dopamine may produce bradykinesia and tremors which are chief motor abnormalities in Parkinson’s Disease (PD).


Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1223
Author(s):  
Mojde Sedaghat ◽  
Yahya Emam ◽  
Ali Mokhtassi-Bidgoli ◽  
Saeid Hazrati ◽  
Claudio Lovisolo ◽  
...  

Strigolactones (SLs) have been implicated in many plant biological and physiological processes, including the responses to abiotic stresses such as drought, in concert with other phytohormones. While it is now clear that exogenous SLs may help plants to survive in harsh environmental condition, the best, most effective protocols for treatment have not been defined yet, and the mechanisms of action are far from being fully understood. In the set of experiments reported here, we contrasted two application methods for treatment with a synthetic analog of SL, GR24. A number of morphometric, physiological and biochemical parameters were measured following foliar application of GR24 or application in the residual irrigation water in winter wheat plants under irrigated and drought stress conditions. Depending on the concentration and the method of GR24 application, differentiated photosynthesis and transpiration rate, stomatal conductance, leaf water potential, antioxidant enzyme activities and yield in drought conditions were observed. We present evidence that different methods of GR24 application led to increased photosynthesis and yield under stress by a combination of drought tolerance and escape factors, which should be considered for future research exploring the potential of this new family of bioactive molecules for practical applications.


1987 ◽  
Vol 33 (9) ◽  
pp. 1615-1618 ◽  
Author(s):  
A Corti ◽  
L Cavenaghi ◽  
E Giani ◽  
G Cassani

Abstract We have developed a new method for quantifying teicoplanin in complex matrixes, a receptor-antibody sandwich assay (RASA). The method is based on bioselective adsorption of teicoplanin onto microtiter plates coated with albumin-epsilon-aminocaproyl-D-alanyl-D-alanine, a synthetic analog of its biological target, and reaction with anti-teicoplanin antibodies. The sandwich complexes are detected by incubation with peroxidase-labeled goat antibodies to rabbit IgGs and chromogenic reaction with o-phenylenediamine. The dose-response curve was linear for teicoplanin concentrations in the range from 0 to 0.15 mg/L. We used the assay to measure teicoplanin concentrations in various biological matrixes. Analytical recovery from serum was 99.5%, the interassay CV was 5.1%, and the detection limit was 30 micrograms/L (P less than 0.01). Mean analytical recoveries from other biological specimens were 98% from ascitic fluid, 100% from pleuric liquid, 104.8% from prostate homogenate, and 98.5% from bronchial expectorate.


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