Response to Comment on “Determining the Ecological Impacts of Organic Contaminants in Biosolids Using a High-Throughput Colorimetric Denitrification Assay: A Case Study with Antimicrobial Agents”

2014 ◽  
Vol 48 (20) ◽  
pp. 12470-12471
Author(s):  
R. M. Holzem ◽  
H. M. Stapleton ◽  
C. K. Gunsch
Keyword(s):  
High Throughput ◽  
Organic Contaminants ◽  
Antimicrobial Agents ◽  
Ecological Impacts

scholarly journals Principled Decision-Making Workflow with Hierarchical Bayesian Models of High-Throughput Dose-Response Measurements

Entropy ◽  
2021 ◽  
Vol 23 (6) ◽  
pp. 727
Author(s):  
Eric J. Ma ◽  
Arkadij Kummer
Keyword(s):  
Decision Making ◽  
High Throughput ◽  
Noisy Data ◽  
Hierarchical Bayesian ◽  
Hierarchical Bayesian Models ◽  
Melting Temperatures ◽  
Hierarchical Bayesian Estimation ◽  
The Face ◽  
Point Data

We present a case study applying hierarchical Bayesian estimation on high-throughput protein melting-point data measured across the tree of life. We show that the model is able to impute reasonable melting temperatures even in the face of unreasonably noisy data. Additionally, we demonstrate how to use the variance in melting-temperature posterior-distribution estimates to enable principled decision-making in common high-throughput measurement tasks, and contrast the decision-making workflow against simple maximum-likelihood curve-fitting. We conclude with a discussion of the relative merits of each workflow.

scholarly journals Action plan for hit identification (APHID): KAT6A as a case study

2020 ◽  
Vol 12 (5) ◽  
pp. 423-437 ◽  
Author(s):  
Xiangyan Yi ◽  
Lian Xue ◽  
Tim Thomas ◽  
Jonathan B Baell
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Action Plan ◽  
Hit Identification

Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.

On the Ethics of International Religious/Spiritual Gatherings and Academic Conferencing in the Era of Global Warming: A Case Study of the Parliament of The World’s Religions Melbourne 2009 - Part 1

2012 ◽  
Vol 16 (2) ◽  
pp. 179-195
Author(s):  
Almut Beringer ◽  
Steven Douglas
Keyword(s):  
Climate Change ◽  
Global Warming ◽  
Global Climate ◽  
Ghg Emissions ◽  
Ecological Impacts ◽  
Peak Oil ◽  
Ethical Challenges ◽  
Academic Events ◽  
Special Responsibility

Global climate change and its impacts have ethical dimensions, for instance carbon footprint equity concerns. World issues, including the state of the ecosphere and biodiver­sity, regularly see political leaders, NGOs, business representatives, religious/spiritual orga­nizations, academics, and others engage in international aviation-dependent meetings to address critical challenges facing humanity and the planet. Yet, climate scientists and advocates call for an 80% reduction in greenhouse gas (GHG) emissions by 2050 to cap the increase in global temperatures to 2ºC. Aviation emissions resulting from international meetings raise questions that are not silenced by GHG emissions offsetting. The era of climate change and ‘peak oil’ poses ethical challenges for holding international in-person religious and academic events, especially when the events propound an environmentalist concern and when aviation use is assumed. This paper raises ques­tions regarding the ecological impacts of large international events and focuses the ‘inconvenient truths’ associated with international aviation in the era of global warming. The Parliament of the World’s Religions, the largest multifaith gathering in the world, serves as a case study. The paper emphasizes the view that faith-based/faith-inspired organizations have a special responsibility for leadership in policy and praxis on the moral imperatives of sustainability, sustainable development and climate justice.

scholarly journals Modelling the Evolutionary Dynamics of Viruses within Their Hosts: A Case Study Using High-Throughput Sequencing

2012 ◽  
Vol 8 (4) ◽  
pp. e1002654 ◽  
Author(s):  
Frédéric Fabre ◽  
Josselin Montarry ◽  
Jérôme Coville ◽  
Rachid Senoussi ◽  
Vincent Simon ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Evolutionary Dynamics

The High-Throughput Synthesis and Phase Characterisation of Amphiphiles: A Sweet Case Study

2014 ◽  
Vol 20 (10) ◽  
pp. 2783-2792 ◽  
Author(s):  
George C. Feast ◽  
Oliver E. Hutt ◽  
Xavier Mulet ◽  
Charlotte E. Conn ◽  
Calum J. Drummond ◽  
...  
Keyword(s):  
High Throughput
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