In Vivo Phycocyanin Flourometry as a Potential Rapid Screening Tool for Predicting Elevated Microcystin Concentrations at Eutrophic Lakes

2012 ◽  
Vol 46 (8) ◽  
pp. 4523-4531 ◽  
Author(s):  
Jason W. Marion ◽  
Jiyoung Lee ◽  
J. R. Wilkins ◽  
Stanley Lemeshow ◽  
Cheonghoon Lee ◽  
...  
Keyword(s):  
Screening Tool ◽  
Rapid Screening ◽  
Eutrophic Lakes

In vitro Lipolysis as a Tool for the Establishment of IVIVC for Lipid-Based Drug Delivery Systems

2019 ◽  
Vol 16 (8) ◽  
pp. 688-697
Author(s):  
Ravinder Verma ◽  
Deepak Kaushik
Keyword(s):  
Drug Delivery ◽  
Ph Value ◽  
Electron Paramagnetic Resonance Spectroscopy ◽  
Rapid Screening ◽  
Resonance Spectroscopy ◽  
Fed State ◽  
In Vitro Lipolysis ◽  
Ph Stat

: In vitro lipolysis has emerged as a powerful tool in the development of in vitro in vivo correlation for Lipid-based Drug Delivery System (LbDDS). In vitro lipolysis possesses the ability to mimic the assimilation of LbDDS in the human biological system. The digestion medium for in vitro lipolysis commonly contains an aqueous buffer media, bile salts, phospholipids and sodium chloride. The concentrations of these compounds are defined by the physiological conditions prevailing in the fasted or fed state. The pH of the medium is monitored by a pH-sensitive electrode connected to a computercontrolled pH-stat device capable of maintaining a predefined pH value via titration with sodium hydroxide. Copenhagen, Monash and Jerusalem are used as different models for in vitro lipolysis studies. The most common approach used in evaluating the kinetics of lipolysis of emulsion-based encapsulation systems is the pH-stat titration technique. This is widely used in both the nutritional and the pharmacological research fields as a rapid screening tool. Analytical tools for the assessment of in vitro lipolysis include HPLC, GC, HPTLC, SEM, Cryo TEM, Electron paramagnetic resonance spectroscopy, Raman spectroscopy and Nanoparticle Tracking Analysis (NTA) for the characterization of the lipids and colloidal phases after digestion of lipids. Various researches have been carried out for the establishment of IVIVC by using in vitro lipolysis models. The current publication also presents an updated review of various researches in the field of in vitro lipolysis.

scholarly journals A rapid screening tool for psychological distress in children 3–6years old: results of a validation study

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Caroline Marquer ◽  
Caroline Barry ◽  
Yoram Mouchenik ◽  
Sarah Hustache ◽  
Douma M Djibo ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Validation Study ◽  
Screening Tool ◽  
Rapid Screening

Rapid screening of antifungal agents for in-vivo activity

1959 ◽  
Vol 77 (1) ◽  
pp. 302-306 ◽  
Author(s):  
R. E. M. Thompson ◽  
F. O'Grady
Keyword(s):  
Antifungal Agents ◽  
Rapid Screening

scholarly journals Direct neuronal reprogramming by temporal identity factors

2021 ◽  
Author(s):  
Camille Boudreau-Pinsonneault ◽  
Awais Javed ◽  
Michel Fries ◽  
Pierre Mattar ◽  
Michel Cayouette
Keyword(s):  
Gene Expression ◽  
Expression System ◽  
Lineage Tracing ◽  
Developmental Competence ◽  
Rapid Screening ◽  
Mouse Retina ◽  
Genetic Lineage ◽  
Differentiated Cells ◽  
Temporal Identity

Temporal identity factors are sufficient to reprogram developmental competence of neural progenitors, but whether they could also reprogram the identity of fully differentiated cells is unknown. To address this question, we designed a conditional gene expression system combined with genetic lineage tracing that allows rapid screening of potential reprogramming factors in the mouse retina. Using this assay, we report that co-expression of the early temporal identity transcription factor Ikzf1, together with Ikzf4, another Ikaros family member, is sufficient to directly convert adult Muller glial cells into neuron-like cells in vivo, without inducing a proliferative progenitor state. scRNA-seq analysis shows that the reprogrammed cells share some transcriptional signatures with both cone photoreceptors and bipolar cells. Furthermore, we show that co-expression of Ikzf1 and Ikzf4 can reprogram mouse embryonic fibroblasts to induced neurons by remodeling chromatin and promoting a neuronal gene expression program. This work uncovers general neuronal reprogramming properties for temporal identity factors in differentiated cells, opening new opportunities for cell therapy development.

(Keynote) An Automatic Rapid Screening Tool for Fast Ionic Conductors

2020 ◽  
Vol MA2020-02 (5) ◽  
pp. 869-869
Author(s):  
Kia Chai Phuah ◽  
Haomin Chen ◽  
Xin Zhang ◽  
Ruoyu Dai ◽  
Anastassia Sorkin ◽  
...  
Keyword(s):  
Screening Tool ◽  
Rapid Screening ◽  
Ionic Conductors ◽  
Fast Ionic Conductors

A rapid screening tool for detecting malnutrition

2003 ◽  
Vol 22 ◽  
pp. S6-S7 ◽  
Author(s):  
A. van Gossum ◽  
L. Drumel ◽  
C. Montoisy ◽  
M. Arvanitaki ◽  
S. Vereecken
Keyword(s):  
Screening Tool ◽  
Rapid Screening
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