Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

2011 ◽  
Vol 45 (17) ◽  
pp. 7473-7480 ◽  
Author(s):  
Fangxia Shen ◽  
Miaomiao Tan ◽  
Zhenxing Wang ◽  
Maosheng Yao ◽  
Zhenqiang Xu ◽  
...  
Keyword(s):  
Real Time ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Air Sampling ◽  
Sampling Techniques ◽  
Real Time Monitoring ◽  
Biological Aerosols ◽  
Effect Transistor

Real-time monitoring of geosmin based on an aptamer-conjugated graphene field-effect transistor

2021 ◽  
Vol 174 ◽  
pp. 112804
Author(s):  
Seon Joo Park ◽  
Sung Eun Seo ◽  
Kyung Ho Kim ◽  
Sang Hun Lee ◽  
Jinyeong Kim ◽  
...  
Keyword(s):  
Real Time ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Real Time Monitoring ◽  
Graphene Field Effect Transistor ◽  
Effect Transistor

scholarly journals Real-Time Monitoring of a Botulinum Neurotoxin Using All-Carbon Nanotube-Based Field-Effect Transistor Devices

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4235 ◽  
Author(s):  
Nam Lee ◽  
Seung-Hoon Nahm ◽  
Insung Choi
Keyword(s):  
Carbon Nanotube ◽  
Real Time ◽  
Field Effect ◽  
Botulinum Neurotoxin ◽  
Field Effect Transistor ◽  
Detection System ◽  
High Sensitivity ◽  
Real Time Monitoring ◽  
Unique Peptide ◽  
Effect Transistor

The possibility of exposure to botulinum neurotoxin (BoNT), a powerful and potential bioterrorism agent, is considered to be ever increasing. The current gold-standard assay, live-mouse lethality, exhibits high sensitivity but has limitations including long assay times, whereas other assays evince rapidity but lack factors such as real-time monitoring or portability. In this study, we aimed to devise a novel detection system that could detect BoNT at below-nanomolar concentrations in the form of a stretchable biosensor. We used a field-effect transistor with a p-type channel and electrodes, along with a channel comprising aligned carbon nanotube layers to detect the type E light chain of BoNT (BoNT/E-Lc). The detection of BoNT/E-Lc entailed observing the cleavage of a unique peptide and the specific bonding between BoNT/E-Lc and antibody BoNT/E-Lc (Anti-BoNT/E-Lc). The unique peptide was cleaved by 60 pM BoNT/E-Lc; notably, 52 fM BoNT/E-Lc was detected within 1 min in the device with the antibody in the bent state. These results demonstrated that an all-carbon nanotube-based device (all-CNT-based device) could be produced without a complicated fabrication process and could be used as a biosensor with high sensitivity, suggesting its potential development as a wearable BoNT biosensor.

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