Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice

2015 ◽  
Vol 35 (10) ◽  
pp. 1122-1132 ◽  
Author(s):  
Hailong Hu ◽  
Qian Guo ◽  
Changlin Wang ◽  
Xiao Ma ◽  
Hongjuan He ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Plasma Glucose ◽  
Titanium Dioxide Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species

2019 ◽  
Author(s):  
Di Zhou ◽  
Shuo Han ◽  
Tenglong Yan ◽  
Changmao Long ◽  
Jiayu Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity

2012 ◽  
Vol 17 (8) ◽  
pp. 1083-1098 ◽  
Author(s):  
Jie Li ◽  
Jared Sipple ◽  
Suzette Maynard ◽  
Parinda A. Mehta ◽  
Susan R. Rose ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Reactive Oxygen Species ◽  
Fanconi Anemia ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Naturally high plasma glucose levels in mourning doves (Zenaida macroura) do not lead to high levels of reactive oxygen species in the vasculature

Zoology ◽  
2011 ◽  
Vol 114 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Christina L. Smith ◽  
Matthew Toomey ◽  
Benjimen R. Walker ◽  
Eldon J. Braun ◽  
Blair O. Wolf ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Plasma Glucose ◽  
Reactive Oxygen ◽  
High Plasma ◽  
Oxygen Species ◽  
Zenaida Macroura ◽  
Glucose Levels ◽  
Mourning Doves ◽  
High Plasma Glucose

scholarly journals Targeting mitochondrial biogenesis: a potential approach for preventing and controlling diabetes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ritika Singh ◽  
Lucy Mohapatra ◽  
Alok Shiomurthi Tripathi
Keyword(s):  
Insulin Resistance ◽  
Reactive Oxygen Species ◽  
Mitochondrial Biogenesis ◽  
Diabetic Complications ◽  
Reactive Oxygen ◽  
Main Body ◽  
Oxygen Species ◽  
Treatment And Prevention ◽  
Skeletal Muscle Insulin Resistance ◽  
Mitochondrial Number

Abstract Background Diabetes mellitus is a lingering hyperglycemic ailment resulting in several life-threatening difficulties. Enduring hyperglycemia often persuades the buildup of reactive oxygen species that are the significant pathological makers of diabetic complications. The mitochondrial dysfunction, with mitochondrial damage and too much production of reactive oxygen species, have been proposed to be convoluted in the progress of insulin resistance. Numerous studies advocate that agents that enhance the mitochondrial number and/or decrease their dysfunction, could be greatly helpful in management of diabetes and its complications. Main body Mitochondrial biogenesis is an extremely delimited procedure arbitrated by numerous transcription influences, in which mitochondrial fusion and fission happen in synchronization in a standard vigorous cell. But this synchronization is greatly disturbed in diabetic condition designated by modification in the working of several important transcription factors regulating the expressions of different genes. Numerous preclinical and clinical investigations have suggested that, the compromised functions of mitochondria play a significant protagonist in development of pancreatic β-cell dysfunction, skeletal muscle insulin resistance and several diabetic complications. However, there are several phytoconstituents performing through numerous alleyways, either unswervingly by motivating biogenesis or indirectly by constraining or averting dysfunction and producing a beneficial effect on overall function of the mitochondria. Conclusion This review describes standard mitochondrial physiology and anomalous modifications that transpire in answer to persistent hyperglycemia in diabetes condition. It also discusses about the different phytoconstituents that can affect the biogenesis pathways of mitochondria and thus can be used in the treatment and prevention of diabetes.

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species

2013 ◽  
Vol 230 (1) ◽  
pp. 131-139 ◽  
Author(s):  
Matthew C. Gage ◽  
Nadira Y. Yuldasheva ◽  
Hema Viswambharan ◽  
Piruthivi Sukumar ◽  
Richard M. Cubbon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Flow Patterns ◽  
Oxygen Species ◽  
Disturbed Flow ◽  
Accelerated Atherosclerosis ◽  
Specific Insulin
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