A Prospective Method To Guide Small Molecule Drug Design

2014 ◽  
Vol 92 (5) ◽  
pp. 836-842 ◽  
Author(s):  
Alan T. Johnson
Keyword(s):  
Drug Design ◽  
Small Molecule ◽  
Small Molecule Drug

ChemInform Abstract: Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

ChemInform ◽  
2009 ◽  
Vol 40 (26) ◽  
Author(s):  
Jack A. Bikker ◽  
Natasja Brooijmans ◽  
Allan Wissner ◽  
Tarek S. Mansour
Keyword(s):  
Drug Design ◽  
Small Molecule ◽  
Kinase Domain ◽  
Design Strategies ◽  
Small Molecule Drug ◽  
Kinase Domain Mutations

Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

2009 ◽  
Vol 52 (6) ◽  
pp. 1493-1509 ◽  
Author(s):  
Jack A. Bikker ◽  
Natasja Brooijmans ◽  
Allan Wissner ◽  
Tarek S. Mansour
Keyword(s):  
Drug Design ◽  
Small Molecule ◽  
Kinase Domain ◽  
Design Strategies ◽  
Small Molecule Drug ◽  
Kinase Domain Mutations

Strategies to identify ligands for orphan G-protein-coupled receptors

2002 ◽  
Vol 30 (4) ◽  
pp. 789-793 ◽  
Author(s):  
G. Milligan
Keyword(s):  
Drug Design ◽  
G Protein ◽  
Small Molecule ◽  
Drug Targets ◽  
G Protein Coupled Receptors ◽  
Orphan Receptors ◽  
Protein Targets ◽  
Small Molecule Drug ◽  
Natural Ligands ◽  
G Protein Coupled

G-protein-coupled receptors are the most tractable class of protein targets for small molecule drug design. Sequencing of the human genome allied to bio-informatic analysis has identified a large number of putative receptors for which the natural ligands remain undefined. A range of currently employed and developing strategies to identify ligands that interact with these orphan receptors and to validate them as drug targets are described and discussed.

Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

2021 ◽  
Vol 45 (12) ◽  
pp. 5291-5321
Author(s):  
Tarun Kumar Patel ◽  
Nilanjan Adhikari ◽  
Sk. Abdul Amin ◽  
Swati Biswas ◽  
Tarun Jha ◽  
...  
Keyword(s):  
Drug Design ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Chemotherapeutic Agents ◽  
Drug Molecule ◽  
Lysosomal Ph ◽  
Small Molecule Drug ◽  
Drug Conjugates ◽  
Small Molecule Drugs ◽  
Tumor Environment

Mechanisms of how SMDCs work. Small molecule drugs are conjugated with the targeted ligand using pH sensitive linkers which allow the drug molecule to get released at lower lysosomal pH. It helps to accumulate the chemotherapeutic agents to be localized in the tumor environment upon cleaving of the pH-labile bonds.

Small Molecule Drug Design

2019 ◽  
pp. 741-760 ◽  
Author(s):  
Vartika Tomar ◽  
Mohit Mazumder ◽  
Ramesh Chandra ◽  
Jian Yang ◽  
Meena K. Sakharkar
Keyword(s):  
Drug Design ◽  
Small Molecule ◽  
Small Molecule Drug

The influence of intramolecular sulfur–lone pair interactions on small-molecule drug design and receptor binding

2016 ◽  
Vol 14 (16) ◽  
pp. 3975-3980 ◽  
Author(s):  
B. M. Hudson ◽  
E. Nguyen ◽  
D. J. Tantillo
Keyword(s):  
Natural Products ◽  
Drug Design ◽  
Small Molecule ◽  
Receptor Binding ◽  
Organic Molecules ◽  
Lone Pair ◽  
Small Molecule Drug ◽  
Lone Pair Interactions ◽  
Sulfur Containing ◽  
Pair Interactions

Sulfur–lone pair interactions are important conformational control elements in sulfur-containing heterocycles that abound in pharmaceuticals, natural products, agrochemicals, polymers and other important classes of organic molecules.

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