The influence of intramolecular sulfur–lone pair interactions on small-molecule drug design and receptor binding

2016 ◽  
Vol 14 (16) ◽  
pp. 3975-3980 ◽  
Author(s):  
B. M. Hudson ◽  
E. Nguyen ◽  
D. J. Tantillo
Keyword(s):  
Natural Products ◽  
Drug Design ◽  
Small Molecule ◽  
Receptor Binding ◽  
Organic Molecules ◽  
Lone Pair ◽  
Small Molecule Drug ◽  
Lone Pair Interactions ◽  
Sulfur Containing ◽  
Pair Interactions

Sulfur–lone pair interactions are important conformational control elements in sulfur-containing heterocycles that abound in pharmaceuticals, natural products, agrochemicals, polymers and other important classes of organic molecules.

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