3,5-Diarylisoxazoles: Individualized Three-Step Synthesis and Isomer Determination Using 13C NMR or Mass Spectroscopy

2006 ◽  
Vol 83 (9) ◽  
pp. 1336 ◽  
Author(s):  
Chad E. Stephens ◽  
Reem K. Arafa
Keyword(s):  
Mass Spectroscopy ◽  
13C Nmr ◽  
Isomer Determination

scholarly journals Sintesis Senyawa Turunan Flavanon dan Uji Bioaktivitas Senyawa Kalkon sebagai Senyawa Antara dalam Sintesis Flavanon

2018 ◽  
Vol 8 ◽  
pp. 68-74
Author(s):  
Nur Shidiq ◽  
Agung Rahmadani ◽  
Viriyanata Wijaya ◽  
Laode Rijai
Keyword(s):  
1H Nmr ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Brine Shrimp ◽  
Brine Shrimp Lethality

Golongan metabolit sekunder yang memiliki aktivitas biologi sepeti antikanker, antitumor, antiproliferatif, dan antimikroba adalah golongan flavonoid dimana flavanon merupakan salah satu senyawanya. Dalam penelitian ini senyawa 2-hidroksi-5-kloro asetofenon dan 4-hidroksi benzaldehida direaksikan melalui reaksi Kondensasi Claisen-Schmidt menghasilkan senyawa turunan kalkon yaitu 2’-hidroksi-5’-kloro-4-hidroksikalkon. Kemudian senyawa 6-kloro-4’-hidroksi flavanon disintesis melalui reaksi siklisasi turunan kalkon dengan metode refluks menggunakan asam sulfat di dalam etanol sebagai katalis. Senyawa hasil sintesis dikarakterisasi dengan teknik elusidasi struktur menggunakan  1H-NMR, 13C-NMR dan MS (Mass Spectroscopy). Dilakukan uji aktivitas antioksidan dan uji toksisitas dari senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon hasil sintesis dengan menggunakan metode DPPH dan metode BSLT (Brine Shrimp Lethality Test) dan dihitung nilai IC50 dan LC50 dengan menggunakan analisis Reed and Muench. Nilai IC50 dan LC50 senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon diperoleh 131,19 ppm dan 46,465 ppm

scholarly journals Synthesis of new derivatives of 1-(3-amino-phenyl)-4- benzoyl-5-phenyl-1h-pyrazole-3-carboxylic acid

2010 ◽  
Vol 75 (12) ◽  
pp. 1625-1635 ◽  
Author(s):  
Rahmi Kasimogullari ◽  
Belma Zengin ◽  
Makbule Maden ◽  
Samet Mert ◽  
Cavit Kazaz
Keyword(s):  
Carboxylic Acid ◽  
Hydrazine Hydrate ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Pyrazole Derivatives ◽  
Cyclocondensation Reaction ◽  
Derivatives Of

4-Benzoyl-1-(3-aminophenyl)-5-phenyl-1H-pyrazole-3- carboxylic acid (1) was synthesized according to the literature.1 2-(3- Aminophenyl)-3,4-diphenyl-2H-pyrazolo[3,4-d]pyridazin-7(6H)-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with ?-diketones, ?-ketoesters, ?-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and Mass spectroscopy, as well as elemental analysis.

scholarly journals Synthesis, Characterization and Biological Activity of Novel 1,3,4-Oxadiazole Derivatives of 1,3-Dihydro-1-oxoisobenzofuran-5-carboxylic Acid

2019 ◽  
Vol 32 (1) ◽  
pp. 95-100
Author(s):  
Nunna Madhava Rao ◽  
Tella Lakshmi Viveka ◽  
Koneti Mallikarjuna Raju ◽  
Maringanti Thirumala Chary
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Oxadiazole Derivatives ◽  
Derivatives Of

This work relates to the synthesis of novel 1,3,4-oxadiazole derivatives (5a-h) from 1,3-dihydro-1-oxoisobenzofuran-5-carboxylic acid. The structure of the synthesized compounds were confirmed by using IR, 1H NMR, 13C NMR and mass spectroscopy. Further these synthesized derivatives were subjected to biological activity.

scholarly journals Synthesis, Characterization, Aggregation behaviors, Antioxidant and Anti-inflammatory activities of Unmetalled and metallophthalocyanines bearing 2(3,4-dimethoxyphenyl)ethanol and 4-Hydroxybenzaldehyde groups

2016 ◽  
Vol 5 (6) ◽  
pp. 632-640 ◽  
Author(s):  
Abduallah Sulaiman
Keyword(s):  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Good Activity ◽  
Lipoxygenase Inhibition ◽  
Anti Oxidant ◽  
Aggregation Behaviors ◽  
Anti Inflammatory

Novel metallophthalocyanines (M: Co, Cu, Ni) containing 2(2-methoxyphenyl)ethanol and 3-Hydroxybenzaldehyde groups  were synthesized and characterized.The structures were confirmed by IR, UV/vis, 1H NMR, 13C NMR, mass spectroscopy  and elemental analysis. The aggregation behavior of these compounds was investigated in DMSO.  In addition; the compounds 4-9 were investigated for anti-oxidant activities by super oxide radical; DPPH (2,2-Diphenyl-1-picrylhydrazyl); and hydroxyl radical scavenging assays; in which most of them  displayed significant antioxidant activities. Furthermore; compounds 4-9   were evaluated for anti-inflammatory activity by indirect hemolytic and lipoxygenase inhibition assays and revealed good activity.

scholarly journals PHYTOCHEMICAL STUDY ON THE ETHYLACETATE EXTRACT OF THE LEAVES OF Mesua ferrea LINN

2010 ◽  
Vol 8 (2) ◽  
pp. 242-244 ◽  
Author(s):  
S. M. Mizanur Rahman ◽  
Swati Shabnom ◽  
M. Abdul Quader ◽  
M. Amzad Hossain
Keyword(s):  
Spectral Analysis ◽  
Medicinal Plant ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Spectroscopic Techniques ◽  
Phytochemical Study

Furano-napthyl-hydroxy cyclohexyl type of compound was isolated first times in plant from the ethyl extracts of the leaves of Mesua ferrea. The structure of the compound has been established by the modern spectroscopic techniques such as UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy and identified as 12, 13-furano-8-hydroxy napthyl-6-0-b-2',3',4',6' tetrahydroxy-5',5' dimethyl cyclohexyl ether.   Keywords: Mesua ferrea Linn; Euphorbiaceae; Medicinal plant; new compound; spectral analysis

Synthesis, Glucosylation and Polarographic Studies of Benzofused Pyrimidine Derivatives

2021 ◽  
Vol 6 (3) ◽  
pp. 148-153
Author(s):  
Rajendra K. Wanare ◽  
Yogesh V. Punatkar ◽  
Ravin M. Jugade
Keyword(s):  
1H Nmr ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Tetrabutylammonium Bromide ◽  
Pyrimidine Derivatives

7-Amino-3-methyl-5-(3′-aryl prop-2′-enoyl)-1,2-benzisoxazoles (2a-j) were synthesized by the condensation of 5-acetyl-7-amino-3-methyl-1,2-benzisoxazole (1) with aldehydes. The reaction of products 2a-j with urea produced 7-amino-3-methyl-5-(4′-aryl-2′-pyrimidin-6′-yl)-1,2-benzisoxazole derivatives (3a-j). Glucosylation of 3a-j with 2,3,4,6-tetra-O-acetyl glucuropyranosyl bromide (TAGBr) and tetrabutylammonium bromide (TBAB) gives corresponding glucosylated 7-amino-(β-D-2,3,4,6- tetra-O-acetyl glucopyranosyl)-3-methyl-5-(4′-aryl-2′-pyrimidin-6′-yl)-1,2-benzisoxazoles (4a-j). Glucosylated compounds 4a-j on deacetylation gives target products 7-amino-(β-D-glucopyranosyl)- 3-methyl-5-(4′-aryl-2′-pyrimidin-6′-yl)-1,2-benzisoxazoles (5a-j). Glucosylation and deacetylation reaction carried out by Knenigs-Knorr reaction. All the synthesized products were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectroscopy. The biological and electrochemical activities of all the synthesized compounds were also examined.

scholarly journals BEBERAPA SENYAWA NON AROMATIS DARI DAUN ANDALAS (Morus macroura Miq.)

2015 ◽  
Vol 1 (1) ◽  
pp. 79
Author(s):  
Yelmida A.
Keyword(s):  
Infrared Spectroscopy ◽  
Thin Layer ◽  
Ethyl Acetate ◽  
Mass Spectroscopy ◽  
13C Nmr ◽  
Aromatic Compounds ◽  
Solvent Polarity ◽  
Wax Ester ◽  
Aliphatic Ester ◽  
Long Chain

 ABSTRACT Several non aromatic compounds of the leaf Morus macroura Miq. as the rare Indonesian plant has been extracted using n-hexane as an extractant. The soxletation technique was applied in this extraction. The result are separated by fractionation methods of the liquid vacuum chromatographic and continued with the column gravitation chromatographic. The eluent are n-hexane-ethyl acetate are used in the separation method, based on principles of solvent polarity step by step. These separation was monitoring by  thin layer chromatographic. The identification result by spectroscopy ultraviolet, infrared spectroscopy, mass spectroscopy, 1H-NMR  and   13C-NMR , are four compounds found such as hidroxy tridecanil eicosanoic m.p.67-69 oC, long chain n-alkane m.p. 61-62 oC, long chain aliphatic ester m.p. 65-66 oC and wax ester ketone m.p. 68-70oC. Keywords: non aromatic compound, chromatograhphic

Study of collagen using liquid and solid 13C NMR

1992 ◽  
Vol 89 ◽  
pp. 227-236 ◽  
Author(s):  
M Bonnet ◽  
L Foucat ◽  
J Dupuis ◽  
JP Renou
Keyword(s):  
13C Nmr
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