Impact of Incorporation of High Field FT-NMR Spectroscopy into the Undergraduate Chemistry Curriculum

2002 ◽  
Vol 79 (6) ◽  
pp. 665 ◽  
Author(s):  
David B. Ball ◽  
Randy Miller
Keyword(s):  
Nmr Spectroscopy ◽  
High Field ◽  
Chemistry Curriculum ◽  
Undergraduate Chemistry

Catalyzing learning with green chemistry undergraduate research

2020 ◽  
Vol 5 (11) ◽  
Author(s):  
Lindsey A Welch
Keyword(s):  
Green Chemistry ◽  
Furfuryl Alcohol ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Ethyl Esters ◽  
Transfer Hydrogenation ◽  
Isopropyl Ether ◽  
Chemistry Curriculum ◽  
Undergraduate Chemistry ◽  
Chemistry Research

AbstractGreen chemistry and sustainability are important concepts to incorporate into the undergraduate chemistry curriculum. Through the development of innovative undergraduate chemistry research projects in these areas, retention of students in the physical sciences can be improved. This paper describes two projects in undergraduate catalysis research: hydrogenation of furfural and the esterification of biooil from pyrolyzed wood. Catalytic transfer hydrogenation (CTH) of furfural with Pd/C led to the production of furfuryl alcohol, furfuryl isopropyl ether, 2-methylfuran, and tetrahydrofurfuryl alcohol. The metal chloride additives improved selectivity for furfuryl alcohol and furfuryl isopropyl ether. Catalytic conversion of pyrolyzed wood biooil in ethanol with a solid acid catalyst yielded ethyl esters, including ethyl acetate and ethyl propionate, as characterized by GC/MS These projects are described in the context of engaging undergraduate students in hands-on research for the purpose of improving retention and persistence, as well as preparing young scientists to enter graduate programs and the STEM workforce.

scholarly journals Trichilones A–E: New Limonoids from Trichilia adolfi

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3070
Author(s):  
Mariela Gonzalez-Ramirez ◽  
Ivan Limachi ◽  
Sophie Manner ◽  
Juan C. Ticona ◽  
Efrain Salamanca ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
High Field ◽  
Chemical Constituents ◽  
Ethanol Extract ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Murine Macrophage ◽  
New Metabolites

In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing investigation of the chemical constituents of the ethanol extract of the bark of this medicinal plant yielded the five new limonoids 1–5. They are characterized by having four fused rings and are new examples of prieurianin-type limonoids, having a ε-lactone which in 4 and 5 is α, β- unsaturated. The structures of the isolated metabolites were determined by high field NMR spectroscopy and HR mass spectrometry. The new metabolites were shown to have the ε-lactone fused with a tetrahydrofuran ring which is connected to an oxidized hexane ring joined with a cyclo-pentanone having a 3-furanyl substituent. As the crude extract possesses antileishmanial activity, the compounds were assayed for cytotoxic and antiparasitic activities in vitro in murine macrophage cells (raw 264.7 cells) and in Leishmania amazoniensis as well as L. braziliensis promastigotes. Metabolites 1–3 and 5 showed moderate cytotoxicity (between 30–94 µg/mL) but are not responsible for the antileishmanial effect of the extract.

Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy

2019 ◽  
Vol 171 ◽  
pp. 30-34 ◽  
Author(s):  
Purnima Khandelwal ◽  
Lisa Zhang ◽  
Anjaneya Chimalakonda ◽  
Janet Caceres-Cortes ◽  
Christine Huang ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Field
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