Trends in Aromatic Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes: A Valence Bond Modeling

2011 ◽  
Vol 7 (2) ◽  
pp. 327-339 ◽  
Author(s):  
Sason Shaik ◽  
Petr Milko ◽  
Patric Schyman ◽  
Dandamudi Usharani ◽  
Hui Chen
Keyword(s):  
Cytochrome P450 ◽  
Valence Bond ◽  
Oxidation Reactions ◽  
Cytochrome P450 Enzymes

The Valence Bond Way: Reactivity Patterns of Cytochrome P450 Enzymes and Synthetic Analogs

2010 ◽  
Vol 43 (8) ◽  
pp. 1154-1165 ◽  
Author(s):  
Sason Shaik ◽  
Wenzhen Lai ◽  
Hui Chen ◽  
Yong Wang
Keyword(s):  
Cytochrome P450 ◽  
Valence Bond ◽  
Cytochrome P450 Enzymes ◽  
Synthetic Analogs

Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes

2004 ◽  
Vol 104 (9) ◽  
pp. 3947-3980 ◽  
Author(s):  
Bernard Meunier ◽  
Samuël P. de Visser ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
Oxidation Reactions ◽  
Cytochrome P450 Enzymes ◽  
Mechanism Of Oxidation

A Bioorganometallic Chemistry Overview: From Cytochrome P450 Enzyme Metabolism of Organotin Compounds to Organorhodium-Hydroxytamoxifen Complexes with Potential Anti-Cancer Properties; A 37 Year Perspective at the Interface of Organometallic Chemistry and Biology

2010 ◽  
Vol 63 (11) ◽  
pp. 1505 ◽  
Author(s):  
Richard H. Fish
Keyword(s):  
Cytochrome P450 ◽  
Organotin Compounds ◽  
Cytochrome P450 Enzyme ◽  
Oxidation Reactions ◽  
Tandem Catalysis ◽  
Cytochrome P450 Enzymes ◽  
Exciting Field ◽  
Bioorganometallic Chemistry ◽  
Hydride Reduction ◽  
P450 Enzyme

A 37 year perspective on bioorganometallic chemistry studies, which included metabolism of organotin compounds with cytochrome P450 enzymes, and their biomimics; reactions of organorhodium aqua complexes with nucleobases, nucleosides, and nucleotides; supramolecular organorhodium-nucleobase complexes as hosts for aromatic amino acid and aromatic carboxylic acid guests; regioselective reduction of NAD+ biomimics with an organorhodium hydride; tandem catalysis of an organorhodium hydride reduction to provide a 1,4-NADH biomimic for horse liver dehydrogenase stereoselective reduction of achiral ketones to chiral alcohols, and oxidation reactions with cytochrome P450 enzymes; and organorhodium-hydroxytamoxifen pharmaceuticals, will be presented. Each of these areas of bioorganometallic chemistry will be briefly discussed in this personal synopsis of the new, important, and exciting field of bioorganometallic chemistry, and its impact on metal-based drug research.

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