Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry

2006 ◽  
Vol 106 (7) ◽  
pp. 2794-2810 ◽  
Author(s):  
A. Erik Rubin ◽  
Srinivas Tummala ◽  
Douglas A. Both ◽  
Chenchi Wang ◽  
Edward J. Delaney
Keyword(s):  
Pharmaceutical Industry ◽  
Chemical Process ◽  
Emerging Technologies

Emerging Technologies Supporting Chemical Process R&D and Their Increasing Impact on Productivity in the Pharmaceutical Industry

ChemInform ◽  
2006 ◽  
Vol 37 (41) ◽  
Author(s):  
A. Erik Rubin ◽  
Srinivas Tummala ◽  
Douglas A. Both ◽  
Chenchi Wang ◽  
Edward J. Delaney
Keyword(s):  
Pharmaceutical Industry ◽  
Chemical Process ◽  
Emerging Technologies

Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry

2019 ◽  
Vol 84 (8) ◽  
pp. 4583-4603 ◽  
Author(s):  
Seb Caille ◽  
Sheng Cui ◽  
Margaret M. Faul ◽  
Steven M. Mennen ◽  
Jason S. Tedrow ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Chemical Process ◽  
Process Innovation ◽  
Molecular Complexity

scholarly journals A Bio-logical Approach to Catalysis in the Pharmaceutical Industry

2020 ◽  
Vol 74 (5) ◽  
pp. 407-417
Author(s):  
Greg Mann ◽  
Frédéric V. Stanger
Keyword(s):  
Drug Discovery ◽  
Pharmaceutical Industry ◽  
Chemical Reactions ◽  
Chemical Process ◽  
Chemical Space ◽  
Aqueous Media ◽  
Complex Chemical ◽  
Environmentally Sustainable ◽  
Mild Conditions ◽  
Complex Chemical Reactions

Enzymes have the potential to catalyse complex chemical reactions with unprecedented selectivity, under mild conditions in aqueous media. Accordingly, there is serious interest from the pharmaceutical industry to utilize enzymes as biocatalysts to produce medicines in an environmentally sustainable and economic manner. Prominent advances in the field of biotechnology have transformed this potential into a reality. Using modern protein engineering techniques, in a matter of months it is possible to evolve an enzyme, which fits the demands of a chemical process, or even to catalyse entirely novel chemistry. Consequently, biocatalysis is routinely applied throughout the pharmaceutical industry for a variety of applications, ranging from the manufacture of large volumes of high value blockbuster drugs to expanding the chemical space available for drug discovery.

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