Mechanism of Free-Radical Generation by Nitric Oxide Synthase

2002 ◽  
Vol 102 (4) ◽  
pp. 1191-1200 ◽  
Author(s):  
Gerald M. Rosen ◽  
Pei Tsai ◽  
Sovitj Pou
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Oxide Synthase

Cardiac arrest induces decrease of nitric oxide synthase activity and increase of free radical generation in rat brain regions

1996 ◽  
Vol 220 (3) ◽  
pp. 147-150 ◽  
Author(s):  
Natalia V. Gulyaeva ◽  
Mikhail Yu. Stepanichev ◽  
Mikhail V. Onufriev ◽  
Natalia A. Lazareva ◽  
Yuri V. Zarzhetsky ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiac Arrest ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Rat Brain ◽  
Brain Regions ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals NITRIC OXIDE SYNTHASE INHIBITION ON FREE RADICAL GENERATION DURING CEREBRAL HYPOXIA IN NEWBORN PIGLETS. ▴ 1389

1996 ◽  
Vol 39 ◽  
pp. 234-234 ◽  
Author(s):  
Yoshihiro Numagami ◽  
Alan B Zubrow ◽  
Anli Zhu ◽  
Om P Mishra ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Cerebral Hypoxia ◽  
Free Radical Generation ◽  
Newborn Piglets ◽  
Radical Generation ◽  
Oxide Synthase

The nitric oxide synthase inhibitor NG-nitro-l-arginine decreases defibrillation-induced free radical generation

Resuscitation ◽  
2003 ◽  
Vol 57 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Craig B. Clark ◽  
Yi Zhang ◽  
Sean M. Martin ◽  
L. Ray Davies ◽  
Linjing Xu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase Inhibitor ◽  
Free Radical Generation ◽  
Radical Generation ◽  
Synthase Inhibitor ◽  
Oxide Synthase

A radiometric analysis of nitric oxide synthase activity in Hymenolepis diminuta

Parasitology ◽  
2000 ◽  
Vol 120 (1) ◽  
pp. 91-95 ◽  
Author(s):  
N. B. TERENINA ◽  
M. V. ONUFRIEV ◽  
N. V. GULYAEVA ◽  
A. M. LINDHOLM ◽  
M. K. S. GUSTAFSSON
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Nadph Diaphorase ◽  
Hymenolepis Diminuta ◽  
Complete Reduction ◽  
Radiometric Analysis ◽  
Nos Inhibitors ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from L-arginine and O2 by nitric oxide synthase (NOS). In the synthesis NO and L-citrulline are produced in a stoichiometric 1[ratio ]1 relation. The activity of NOS was analysed in homogenates of the rat tapeworm Hymenolepis diminuta by measuring the formation of L-[3H]citrulline after incubation with L-[3H]arginine. The nature of NOS in H. diminuta was determined by studying the effect of 3 types of NOS inhibitors: (1) L-NAME, (2) EGTA, (3) 7-nitro-indazole. All inhibitors caused a significant but not complete reduction in the formation of L-[3H]citrulline. The results are discussed against the background of nerve cells and fibres positive for NADPH-diaphorase staining in H. diminuta.

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