scholarly journals Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

2010 ◽  
Vol 1 (4) ◽  
pp. 288-305 ◽  
Author(s):  
Ralf Mueller ◽  
Alice L. Rodriguez ◽  
Eric S. Dawson ◽  
Mariusz Butkiewicz ◽  
Thuy T. Nguyen ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
Metabotropic Glutamate

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

MedChemComm ◽  
2011 ◽  
Vol 2 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Andrés A. Trabanco ◽  
Guillaume Duvey ◽  
José María Cid ◽  
Gregor J. Macdonald ◽  
Philippe Cluzeau ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators

N-propyl-5-substituted isoquinolones were identified as mGluR2 PAMs via high-throughput screening (HTS). Initial SAR exploration led to the identification of compound 20.

Alcohol Addiction- Metabotropic Glutamate Receptor Subtype 5 and its Ligands: How They All Come Together?

2018 ◽  
Vol 19 (8) ◽  
pp. 907-915 ◽  
Author(s):  
Jaya Kumar ◽  
Zalina Ismail ◽  
Nurul Hazwani Hatta ◽  
Najwa Baharuddin ◽  
Hermizi Hapidin ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Alcohol Addiction ◽  
Receptor Subtype ◽  
Metabotropic Glutamate
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