New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

MedChemComm ◽  
2011 ◽  
Vol 2 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Andrés A. Trabanco ◽  
Guillaume Duvey ◽  
José María Cid ◽  
Gregor J. Macdonald ◽  
Philippe Cluzeau ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulators ◽  
Metabotropic Glutamate ◽  
Positive Allosteric Modulators

N-propyl-5-substituted isoquinolones were identified as mGluR2 PAMs via high-throughput screening (HTS). Initial SAR exploration led to the identification of compound 20.

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