scholarly journals The Postnatal Development ofd-Serine in the Retinas of Two Mouse Strains, Including a Mutant Mouse with a Deficiency ind-Amino Acid Oxidase and a Serine Racemase Knockout Mouse

2014 ◽  
Vol 5 (9) ◽  
pp. 848-854 ◽  
Author(s):  
Gabriel E. Romero ◽  
Amber D. Lockridge ◽  
Catherine W. Morgans ◽  
Dipankar Bandyopadhyay ◽  
Robert F. Miller
Keyword(s):  
Amino Acid ◽  
Postnatal Development ◽  
Knockout Mouse ◽  
Mutant Mouse ◽  
Serine Racemase ◽  
Mouse Strains ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

scholarly journals Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum

2021 ◽  
Vol 1751 ◽  
pp. 147202
Author(s):  
Shunsuke Takagi ◽  
Darrick T. Balu ◽  
Joseph T. Coyle
Keyword(s):  
Amino Acid ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mouse Striatum

scholarly journals d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia

2007 ◽  
Vol 26 (6) ◽  
pp. 1657-1669 ◽  
Author(s):  
Louise Verrall ◽  
Mary Walker ◽  
Nancy Rawlings ◽  
Isabel Benzel ◽  
James N. C. Kew ◽  
...  
Keyword(s):  
Amino Acid ◽  
Human Brain ◽  
Normal Distribution ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Altered Expression

Behavioral characterization of a mutant mouse strain lacking d-amino acid oxidase activity

2011 ◽  
Vol 217 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Min Zhang ◽  
Michael E. Ballard ◽  
Ana M. Basso ◽  
Natalie Bratcher ◽  
Kaitlin E. Browman ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mouse Strain ◽  
Oxidase Activity ◽  
Mutant Mouse ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mutant Mouse Strain ◽  
Behavioral Characterization

Ketamine enhances the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain

2006 ◽  
Vol 540 (1-3) ◽  
pp. 82-86 ◽  
Author(s):  
Kazuhide Takeyama ◽  
Masanobu Yoshikawa ◽  
Tetsuo Oka ◽  
Mitsuru Kawaguchi ◽  
Toshiyasu Suzuki ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the d-serine levels in rat brain

2007 ◽  
Vol 555 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Atsushi Hashimoto ◽  
Masanobu Yoshikawa ◽  
Hidehiro Andoh ◽  
Hiroshi Yano ◽  
Hideo Matsumoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mk 801

Alteration of intrinsic amounts of d-serine in the mice lacking serine racemase and d-amino acid oxidase

Amino Acids ◽  
2012 ◽  
Vol 43 (5) ◽  
pp. 1919-1931 ◽  
Author(s):  
Yurika Miyoshi ◽  
Ryuichi Konno ◽  
Jumpei Sasabe ◽  
Kyoko Ueno ◽  
Yosuke Tojo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

D-Aspartate oxidase activity and D-aspartate content in a mutant mouse strain lacking D-amino acid oxidase

1990 ◽  
Vol 46 (5) ◽  
pp. 468-470 ◽  
Author(s):  
H. Nagasaki ◽  
R. Yamada ◽  
R. Konno ◽  
Y. Yasumura ◽  
A. Iwashima
Keyword(s):  
Amino Acid ◽  
Mouse Strain ◽  
Oxidase Activity ◽  
Mutant Mouse ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mutant Mouse Strain

Acute treatment with morphine augments the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain

2005 ◽  
Vol 525 (1-3) ◽  
pp. 94-97 ◽  
Author(s):  
Masanobu Yoshikawa ◽  
Hidehiro Andoh ◽  
Kenji Ito ◽  
Toshiyasu Suzuki ◽  
Mitsuru Kawaguchi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Acute Treatment ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

scholarly journals Retinal NMDA receptor function and expression are altered in a mouse lacking d-amino acid oxidase

2013 ◽  
Vol 110 (12) ◽  
pp. 2718-2726 ◽  
Author(s):  
Eric C. Gustafson ◽  
Catherine W. Morgans ◽  
Merve Tekmen ◽  
Steven J. Sullivan ◽  
Manuel Esguerra ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nmda Receptors ◽  
Ampa Receptor ◽  
Mutant Mouse ◽  
Ganglion Cells ◽  
Synaptic Activity ◽  
Acid Oxidase ◽  
Inner Plexiform Layer ◽  
Wild Type ◽  
Amino Acid Oxidase

d-serine is present in the vertebrate retina and serves as a coagonist for the N-methyl-d-aspartate (NMDA) receptors of ganglion cells. Although the enzyme d-amino acid oxidase (DAO) has been implicated as a pathway for d-serine degradation, its role in the retina has not been established. In this study, we investigated the role of DAO in regulating d-serine levels using a mutant mouse line deficient in DAO (ddY/DAO−) and compared these results with their wild-type counterparts (ddY/DAO+). Our results show that DAO is functionally present in the mouse retina and normally serves to reduce the background levels of d-serine. The enzymatic activity of DAO was restricted to the inner plexiform layer as determined by histochemical analysis. Using capillary electrophoresis, we showed that mutant mice had much higher levels of d-serine. Whole cell recordings from identified retinal ganglion cells demonstrated that DAO-deficient animals had light-evoked synaptic activity strongly biased toward a high NMDA-to-AMPA receptor ratio. In contrast, recordings from wild-type ganglion cells showed a more balanced ratio between the two receptor subclasses. Immunostaining for AMPA and NMDA receptors was carried out to compare the two receptor ratios by quantitative immunofluorescence. These studies revealed that the mutant mouse had a significantly higher representation of NMDA receptors compared with the wild-type controls. We conclude that 1) DAO is an important regulatory enzyme and normally functions to reduce d-serine levels in the retina, and 2) d-serine levels play a role in the expression of NMDA receptors and the NMDA-to-AMPA receptor ratio.

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