Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the d-serine levels in rat brain

2007 ◽  
Vol 555 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Atsushi Hashimoto ◽  
Masanobu Yoshikawa ◽  
Hidehiro Andoh ◽  
Hiroshi Yano ◽  
Hideo Matsumoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mk 801

Ketamine enhances the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain

2006 ◽  
Vol 540 (1-3) ◽  
pp. 82-86 ◽  
Author(s):  
Kazuhide Takeyama ◽  
Masanobu Yoshikawa ◽  
Tetsuo Oka ◽  
Mitsuru Kawaguchi ◽  
Toshiyasu Suzuki ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain

2004 ◽  
Vol 131 (1-2) ◽  
pp. 141-144 ◽  
Author(s):  
Masanobu Yoshikawa ◽  
Tetsuo Oka ◽  
Mitsuru Kawaguchi ◽  
Atsushi Hashimoto
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mk 801

Acute treatment with morphine augments the expression of serine racemase and d-amino acid oxidase mRNAs in rat brain

2005 ◽  
Vol 525 (1-3) ◽  
pp. 94-97 ◽  
Author(s):  
Masanobu Yoshikawa ◽  
Hidehiro Andoh ◽  
Kenji Ito ◽  
Toshiyasu Suzuki ◽  
Mitsuru Kawaguchi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Acute Treatment ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

scholarly journals Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat

2021 ◽  
Author(s):  
Hong Wei ◽  
Zuyue Chen ◽  
Ari Koivisto ◽  
Antti Pertovaara
Keyword(s):  
Amino Acid ◽  
Nmda Receptors ◽  
Receptor Antagonist ◽  
Gap Junction ◽  
Male Rats ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mk 801 ◽  
Mechanical Hypersensitivity ◽  
Pain Hypersensitivity

Abstract Background Earlier studies show that endogenous sphingolipids can induce pain hypersensitivity, activation of spinal astrocytes, release of proinflammatory cytokines and activation of TRPM3 channel. Here we studied whether the development of pain hypersensitivity induced by sphingolipids in the spinal cord can be prevented by pharmacological inhibition of potential downstream mechanisms that we hypothesized to include TRPM3, σ1 and NMDA receptors, gap junctions and D-amino acid oxidase. Methods Experiments were performed in adult male rats with a chronic intrathecal catheter for spinal drug administrations. Mechanical nociception was assessed with monofilaments and heat nociception with radiant heat. N,N-dimethylsphingosine (DMS) was administered to induce pain hypersensitivity. Ononetin, isosakuranetin, naringenin (TRPM3 antagonists), BD-1047 (σ1 receptor antagonist), carbenoxolone (a gap junction decoupler), MK-801 (NMDA receptor antagonist) and AS-057278 (inhibitor of D-amino acid oxidase, DAAO) were used to prevent the DMS-induced hypersensitivity, and pregnenolone sulphate (TRPM3 agonist) to recapitulate hypersensitivity. Results DMS alone produced within 15 min a dose-related mechanical hypersensitivity that lasted at least 24 h, without effect on heat nociception. Preemptive treatments with ononetin, isosakuranetin, naringenin, BD-1047, carbenoxolone, MK-801 or AS-057278 attenuated the development of the DMS-induced hypersensitivity, but had no effects when administered alone. Pregnenolone sulphate (TRPM3 agonist) alone induced a dose-related mechanical hypersensitivity that was prevented by ononetin, isosakuranetin and naringenin. Conclusions Among spinal pronociceptive mechanisms activated by DMS are TRPM3, gap junction coupling, the σ1 and NMDA receptors, and DAAO.

scholarly journals Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum

2021 ◽  
Vol 1751 ◽  
pp. 147202
Author(s):  
Shunsuke Takagi ◽  
Darrick T. Balu ◽  
Joseph T. Coyle
Keyword(s):  
Amino Acid ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Mouse Striatum

scholarly journals d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia

2007 ◽  
Vol 26 (6) ◽  
pp. 1657-1669 ◽  
Author(s):  
Louise Verrall ◽  
Mary Walker ◽  
Nancy Rawlings ◽  
Isabel Benzel ◽  
James N. C. Kew ◽  
...  
Keyword(s):  
Amino Acid ◽  
Human Brain ◽  
Normal Distribution ◽  
Serine Racemase ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Altered Expression

scholarly journals The Postnatal Development ofd-Serine in the Retinas of Two Mouse Strains, Including a Mutant Mouse with a Deficiency ind-Amino Acid Oxidase and a Serine Racemase Knockout Mouse

2014 ◽  
Vol 5 (9) ◽  
pp. 848-854 ◽  
Author(s):  
Gabriel E. Romero ◽  
Amber D. Lockridge ◽  
Catherine W. Morgans ◽  
Dipankar Bandyopadhyay ◽  
Robert F. Miller
Keyword(s):  
Amino Acid ◽  
Postnatal Development ◽  
Knockout Mouse ◽  
Mutant Mouse ◽  
Serine Racemase ◽  
Mouse Strains ◽  
Acid Oxidase ◽  
Amino Acid Oxidase
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