Lipoic Acid and Dihydrolipoic Acid. A Comprehensive Theoretical Study of Their Antioxidant Activity Supported by Available Experimental Kinetic Data

2014 ◽  
Vol 54 (6) ◽  
pp. 1642-1652 ◽  
Author(s):  
Romina Castañeda-Arriaga ◽  
J. Raul Alvarez-Idaboy
Keyword(s):  
Antioxidant Activity ◽  
Lipoic Acid ◽  
Kinetic Data ◽  
Theoretical Study ◽  
Dihydrolipoic Acid

The Contributions Of Antioxidant Activity Of Lipoic Acid In Reducing Neurogenerative Progression Of Parkinson’s Disease: A Review

2010 ◽  
Vol 121 (2) ◽  
pp. 51-57 ◽  
Author(s):  
Dayane Pessoa De Araújo ◽  
Rodrigo De Freitas Guimarães Lobato ◽  
José Rodolfo Lopes De Paiva Cavalcanti ◽  
Luis Rafael Leite Sampaio ◽  
Paulo Victor Pontes Araújo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Antioxidant Activity ◽  
Parkinson's Disease ◽  
Lipoic Acid

scholarly journals Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Anna Bilska-Wilkosz ◽  
Magdalena Kotańska ◽  
Magdalena Górny ◽  
Barbara Filipek ◽  
Małgorzata Iciek
Keyword(s):  
Blood Pressure ◽  
Rat Liver ◽  
Lipoic Acid ◽  
Aldh Activity ◽  
Dihydrolipoic Acid ◽  
Treatment Groups ◽  
Intracellular Compartments ◽  
Electrocardiogram Ecg ◽  
First Time ◽  
All Treatment

The exogenous lipoic acid (LA) is successfully used as a drug in the treatment of many diseases. It is assumed that after administration, LA is transported to the intracellular compartments and reduced to dihydrolipoic acid (DHLA) which is catalyzed by NAD(P)H-dependent enzymes. The purpose of this study was to investigate whether LA can attenuate cardiovascular disturbances induced by ethanol (EtOH) and disulfiram (DSF) administration separately or jointly in rats. For this purpose, we measured systolic and diastolic blood pressure, recorded electrocardiogram (ECG), and estimated mortality of rats. We also studied the activity of aldehyde dehydrogenase (ALDH) in the rat liver. It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication. The administration of EtOH, LA, and DSF separately or jointly affected the ALDH activity in the rat liver since a significant decrease in the activity of the enzyme was observed in all treatment groups. The results indicating that LA is an inhibitor of ALDH activity are very surprising.

scholarly journals Theoretical Study of the Iron Complexes with Lipoic and Dihydrolipoic Acids: Exploring Secondary Antioxidant Activity

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 674
Author(s):  
Roger Monreal-Corona ◽  
Jesse Biddlecombe ◽  
Angela Ippolito ◽  
Nelaine Mora-Diez
Keyword(s):  
Antioxidant Activity ◽  
Electron Transfer ◽  
Rate Constant ◽  
Thermodynamic Stability ◽  
Rate Constants ◽  
Theoretical Study ◽  
Oh Radicals ◽  
Single Electron Transfer ◽  
Coordination Numbers ◽  
Ph Conditions

The thermodynamic stability of twenty-nine Fe(III) complexes with various deprotonated forms of lipoic (LA) and dihydrolipoic (DHLA) acids, with coordination numbers 4, 5 and 6, is studied at the M06(SMD)/6-31++G(d,p) level of theory in water under physiological pH conditions at 298.15 K. Even though the complexes with LA- are more stable than those with DHLA−, the most thermodynamically stable Fe(III) complexes involve DHLA2−. The twenty-four exergonic complexes are used to evaluate the secondary antioxidant activity of DHLA and LA relative to the Fe(III)/Fe(II) reduction by O2•− and ascorbate. Rate constants for the single-electron transfer (SET) reactions are calculated. The thermodynamic stability of the Fe(III) complexes does not fully correlate with the rate constant of their SET reactions, but more exergonic complexes usually exhibit smaller SET rate constants. Some Cu(II) complexes and their reduction to Cu(I) are also studied at the same level of theory for comparison. The Fe(III) complexes appear to be more stable than their Cu(II) counterparts. Relative to the Fe(III)/Fe(II) reduction with ascorbate, DHLA can fully inhibit the formation of •OH radicals, but not by reaction with O2•−. Relative to the Cu(II)/Cu(I) reduction with ascorbate, the effects of DHLA are moderate/high, and with O2•− they are minor. LA has minor to negligible inhibition effects in all the cases considered.

scholarly journals Gas-phase reactivity of CH3OH toward OH at interstellar temperatures (11.7–177.5 K): experimental and theoretical study

2019 ◽  
Vol 21 (13) ◽  
pp. 6942-6957 ◽  
Author(s):  
Antonio J. Ocaña ◽  
Sergio Blázquez ◽  
Alexey Potapov ◽  
Bernabé Ballesteros ◽  
André Canosa ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Theoretical Analysis ◽  
Gas Phase ◽  
Kinetic Data ◽  
Theoretical Study ◽  
Product Distributions

New kinetic data and product distributions have been obtained using the experimental CRESU technique combined with a theoretical analysis of the reaction mechanism. The astrophysical implications of fast CH3O and CH2OH formation are discussed.

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